B6Q8T5 (AMPP3_PENMQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase pepP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	pepP
ORF Names:	PMAA_069810

Organism

Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) [Complete proteome]

Taxonomic identifier

441960 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Talaromyces › Penicillium marneffei

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Probable Xaa-Pro aminopeptidase pepP		PRO_0000411883
Sites
	Metal binding	261	1	Manganese 2 By similarity
	Metal binding	272	1	Manganese 1 By similarity
	Metal binding	272	1	Manganese 2 By similarity
	Metal binding	395	1	Manganese 1 By similarity
	Metal binding	435	1	Manganese 1 By similarity
	Metal binding	435	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6Q8T5 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: 146C726B9A8AF0C3	FASTA	465	51,734
	10 20 30 40 50 60 MTSTDGILAG KYPAKAHARR VVEYLRQNGF QGDGVLYLEA QKTRMIEDND SEQPFRQRRF 70 80 90 100 110 120 FFYLSGCLLP DAHLTYHIST DKLTLFIPPL DPESVIWSGL PLSPAQAKEL YDVDEVLYTT 130 140 150 160 170 180 DVNPTLAHLA SKVGFVFAID GQISDDVSLK SFPDTDKVAL KTAIEECRAV KDAYEVAMIR 190 200 210 220 230 240 KANDVTSQAH VAVLKAAKSA TNERELEAAF IGTCIAQGCR EMAYHPIVAS GTSSATLHYV 250 260 270 280 290 300 NNDEPLIDSS TNKKKLNLLL DAAGEYKAYC ADVTRTFPLS GKFSPESREI YDIVLEMQTE 310 320 330 340 350 360 SLAMLKEGVL WEDVHITAHR VAIKGLLKLG ILRGSEEELL EKRVSVAFFP HGLGHYLGMD 370 380 390 400 410 420 THDTGGHANY ADKDKMFQYL RVRGKLPAGS VITVEPGVYF CRFIIEPYLK DSELSKYIDA 430 440 450 460 DVLEKYWEVG GVRIEDNIHI TKEGHENLTT APKTADQVEL MINGS

References

[1]

"The genome sequence of Penicillium marneffei strain ATCC 18224." Fedorova N.D., Joardar V.S., Maiti R., Schobel S., Amedeo P., Galens K., Inman J.M., White O.R., Whitty B.R., Wortman J.R., Nierman W.C. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 18224 / CBS 334.59 / QM 7333.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS995900 Genomic DNA. Translation: EEA25889.1.
RefSeq	XP_002146436.1. XM_002146400.1.
3D structure databases
ProteinModelPortal	B6Q8T5.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7024116.
Phylogenomic databases
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_PENMQ

Accession

Primary (citable) accession number: B6Q8T5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	December 16, 2008
Last modified:	March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program