B6KNM2 (B6KNM2_TOXGO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

ORF Names:

TGME49_053900 EMBL EEB02305.1

Organism

Toxoplasma gondii

Taxonomic identifier

5811 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Conoidasida › Coccidia › Eucoccidiorida › Eimeriorina › Sarcocystidae › Toxoplasma

Protein attributes

Sequence length	658 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Molecular function	Lyase RuleBase RU000515 EMBL EEB02305.1
Technical term	3D-structure PDB 3OBK
Gene Ontology (GO)
Biological_process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: InterPro porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B6KNM2 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: CC656D2E97D5A641	FASTA	658	71,374
	10 20 30 40 50 60 MRPLSLFFRL SFLLFVLLFP SPSVDALLQS SSVAGSFPTP ASVASSGRSV SPHNALYVHS 70 80 90 100 110 120 RTEATAGLPS GASLAITLNG ESEEPRRNGA RRKGSKSLGF LVAPPLSRSC TTEQTGELFS 130 140 150 160 170 180 GGAKVRGLNV QVTASPVGRE LASSLRSRAS EPEIRQLAAS PIFGAPKPFS SCPCSSSSRS 190 200 210 220 230 240 SCAAHPSALL PEVCSFVSRR GARRNLGAQR GRGPGARGQR LGAAAGPTPV GKGTPGGAKG 250 260 270 280 290 300 QFRGGMSAQK GAVHQEPLRG RLEEDEEEED EFEDDEFDDE DEGEDEGEDE EYDEEDDEDY 310 320 330 340 350 360 DPMTPRGPLD NNNYGEVWLP IQARPRRNRK NRAVRQLVQE NLVKPSSLIY PLFVHDEETS 370 380 390 400 410 420 VPIPSMPGQS RLSMEDLLKE VGEARSYGIK AFMLFPKVDD ELKSVMAEES YNPDGLLPRA 430 440 450 460 470 480 IMALKEAFPD VLLLADVALD PYSSMGHDGV VDEQSGKIVN DLTVHQLCKQ AITLARAGAD 490 500 510 520 530 540 MVCPSDMMDG RVSAIRESLD MEGCTDTSIL AYSCKYASSF YGPFRDALDS HMVGGTDKKT 550 560 570 580 590 600 YQMDPSNSRE AEREAEADAS EGADMLMVKP GLPYLDVLAK IREKSKLPMV AYHVSGEYAM 610 620 630 640 650 LKAAAEKGYI SEKDTVLEVL KSFRRAGADA VATYYAKEAA KWMVEDMKGT QKFTEPCY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of Toxoplasma gondii ME49." Lorenzi H., Caler E., Galinsky K., Schobel S., Brunk B.P., Roos D.S., Paulsen I. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ME49 EMBL EEB02305.1.
[2]	"Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation." Jaffe E.K., Shanmugam D., Gardberg A., Dieterich S., Sankaran B., Stewart L.J., Myler P.J., Roos D.S. J. Biol. Chem. 286:15298-15307(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 303-658.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DS984739 Genomic DNA. Translation: EEB02305.1.

RefSeq

XP_002369445.1. XM_002369404.1.

UniGene

Tgo.332.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3OBK	X-ray	2.50	A/B/C/D/E/F/G/H	303-658	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

7900026.

KEGG

tgo:TGME49_053900.

Organism-specific databases

EuPathDB

ToxoDB:TGME49_253900.

Phylogenomic databases

KO

K01698.

ProtClustDB

CLSZ2432714.

Family and domain databases

Gene3D

3.20.20.70. 1 hit.

InterPro

IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]

PANTHER

PTHR11458. PTHR11458. 1 hit.

Pfam

PF00490. ALAD. 1 hit.
[Graphical view]

PRINTS

PR00144. DALDHYDRTASE.

SMART

SM01004. ALAD. 1 hit.
[Graphical view]

PROSITE

PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

B6KNM2_TOXGO

Accession

Primary (citable) accession number: B6KNM2

Entry history

Integrated into UniProtKB/TrEMBL:	December 16, 2008
Last sequence update:	December 16, 2008
Last modified:	March 6, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)