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B6K7U7

- KEX1_SCHJY

UniProt

B6K7U7 - KEX1_SCHJY

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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771PROSITE-ProRule annotation
Active sitei370 – 3701PROSITE-ProRule annotation
Active sitei439 – 4391PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:SJAG_04819
OrganismiSchizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Taxonomic identifieri402676 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000001744: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 522500Pheromone-processing carboxypeptidase kex1PRO_0000411944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 478456LumenalSequence AnalysisAdd
BLAST
Topological domaini500 – 52223CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei479 – 49921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi417 – 4204Poly-Ala

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6K7U7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSFLLRVA GLFFLQFNSA QAKSQVHEQW HVSSIPNVPA GYTGSLHSGY
60 70 80 90 100
LNLTDKLEGD LFFTLYGSEN EVHQNRTIIW LNGGPGCSSE DGSMLELGPL
110 120 130 140 150
RLTNDSLVYY NAASWVRLGN VLFVDQPMGT GFSFADTRDA ILNDNEKMSN
160 170 180 190 200
DFAYFLQEFV KAFPEYATDT WYIAGESFAG QYIPAIAKKV IDSDIVNLSG
210 220 230 240 250
IAIGNGWIEP ASHYLTYLDY LVERGLLERG SALFEALTAV QAKCLMSLEQ
260 270 280 290 300
SASGMLEDEN SCDKYLFDIL FSVSDKSGEF CFNMYDVTLT SPYPSCGMEW
310 320 330 340 350
PLELPALTDF LSSPDVMKAL HVASDKVSRW EECSSLVSNF YADTNVFRTR
360 370 380 390 400
FTIAELLEEI PVMLFYGEND FLCNYVSGEF LISNLEWSGK RGFENASNAD
410 420 430 440 450
WYPRYSEANT LEYGQYAAAA GIIHSERNLT YATIRNSSHM VPYDHPYEML
460 470 480 490 500
ALVSAFFDND FSQILMLPDP VTIVPNHSFL SIFLWVMAGI LAFSAIGAIC
510 520
YYSYRHIRSR YDSYTPIQEE SA
Length:522
Mass (Da):58,658
Last modified:December 16, 2008 - v1
Checksum:iBD38BFEC56194DDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KE651168 Genomic DNA. Translation: EEB09601.1.
RefSeqiXP_002175894.1. XM_002175858.1.

Genome annotation databases

EnsemblFungiiEEB09601; EEB09601; SJAG_04819.
GeneIDi7049399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
KE651168 Genomic DNA. Translation: EEB09601.1 .
RefSeqi XP_002175894.1. XM_002175858.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.A67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EEB09601 ; EEB09601 ; SJAG_04819 .
GeneIDi 7049399.

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: yFS275 / FY16936.

Entry informationi

Entry nameiKEX1_SCHJY
AccessioniPrimary (citable) accession number: B6K7U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3