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B6K7U7 (KEX1_SCHJY) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:SJAG_04819
OrganismSchizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast) [Complete proteome]
Taxonomic identifier402676 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 522500Pheromone-processing carboxypeptidase kex1
PRO_0000411944

Regions

Topological domain23 – 478456Lumenal Potential
Transmembrane479 – 49921Helical; Potential
Topological domain500 – 52223Cytoplasmic Potential
Compositional bias417 – 4204Poly-Ala

Sites

Active site1771 By similarity
Active site3701 By similarity
Active site4391 By similarity

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential
Glycosylation3951N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B6K7U7 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: BD38BFEC56194DDA

FASTA52258,658
        10         20         30         40         50         60 
MSLSFLLRVA GLFFLQFNSA QAKSQVHEQW HVSSIPNVPA GYTGSLHSGY LNLTDKLEGD 

        70         80         90        100        110        120 
LFFTLYGSEN EVHQNRTIIW LNGGPGCSSE DGSMLELGPL RLTNDSLVYY NAASWVRLGN 

       130        140        150        160        170        180 
VLFVDQPMGT GFSFADTRDA ILNDNEKMSN DFAYFLQEFV KAFPEYATDT WYIAGESFAG 

       190        200        210        220        230        240 
QYIPAIAKKV IDSDIVNLSG IAIGNGWIEP ASHYLTYLDY LVERGLLERG SALFEALTAV 

       250        260        270        280        290        300 
QAKCLMSLEQ SASGMLEDEN SCDKYLFDIL FSVSDKSGEF CFNMYDVTLT SPYPSCGMEW 

       310        320        330        340        350        360 
PLELPALTDF LSSPDVMKAL HVASDKVSRW EECSSLVSNF YADTNVFRTR FTIAELLEEI 

       370        380        390        400        410        420 
PVMLFYGEND FLCNYVSGEF LISNLEWSGK RGFENASNAD WYPRYSEANT LEYGQYAAAA 

       430        440        450        460        470        480 
GIIHSERNLT YATIRNSSHM VPYDHPYEML ALVSAFFDND FSQILMLPDP VTIVPNHSFL 

       490        500        510        520 
SIFLWVMAGI LAFSAIGAIC YYSYRHIRSR YDSYTPIQEE SA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
KE651168 Genomic DNA. Translation: EEB09601.1.
RefSeqXP_002175894.1. XM_002175858.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEEB09601; EEB09601; SJAG_04819.
GeneID7049399.

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_SCHJY
AccessionPrimary (citable) accession number: B6K7U7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: March 19, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries