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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Helicobacter pylori (strain P12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:HPP12_0089
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000008198 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000998731 – 450Probable malate:quinone oxidoreductaseAdd BLAST450

Structurei

3D structure databases

ProteinModelPortaliB6JPI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000102104.
KOiK00116.
OMAiDMGEAKI.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

B6JPI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMEFDAVII GGGVSGCATF YTLSEYSSLK RVAIVEKCSK LAQISSSAKA
60 70 80 90 100
NSQTIHDGSI ETNYTPEKAK KVRLSAYKTR QYALNKGLQN EVIFETQKMA
110 120 130 140 150
IGVGDEECEF MKKRYESFKE IFVGLEEFDK QKIKELEPNV ILGANGIDRH
160 170 180 190 200
ENIVGHGYQK DWSTMNFAKL SENFVEEALK LRPNNQVFLN FKVKKIEKRN
210 220 230 240 250
DTYAVISEDA EEVYAKFVLV NAGSYALPLA QSMGYGLDLG CLPVAGSFYF
260 270 280 290 300
VPDLLKGKVY TVQNPKLPFA AVHGDPDAVI KGKTRIGPTA LTMPKLERNK
310 320 330 340 350
CWLKGISLEL LKMDLNKDVF KIAFDLMSDK EIRNYVFKNM VFELPIIGKR
360 370 380 390 400
KFLKDAQKII PSLSLEDLEY AHGFGEVRPQ VLDRTKRKLE LGEKKICTHK
410 420 430 440 450
GITFNMTPSP GATSCLQNAL VDSQEIAAYL GESFELERFY KDLSPEELEN
Length:450
Mass (Da):50,670
Last modified:December 16, 2008 - v1
Checksum:iD299825BBA39F3B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ07249.1.
RefSeqiWP_000061455.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ07249; ACJ07249; HPP12_0089.
KEGGihpp:HPP12_0089.

Similar proteinsi

Entry informationi

Entry nameiMQO_HELP2
AccessioniPrimary (citable) accession number: B6JPI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: October 25, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families