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Protein

60 kDa chaperonin

Gene

groL

Organism
Helicobacter pylori (strain P12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:HPP12_0008
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000008198 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001300231 – 54660 kDa chaperoninAdd BLAST546

Proteomic databases

PRIDEiB6JPA7.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

SMRiB6JPA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076290.
KOiK04077.
OMAiTDTDKME.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

B6JPA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIKFSDS ARNLLFEGVR QLHDAVKVTM GPRGRNVLIQ KSYGAPSITK
60 70 80 90 100
DGVSVAKEIE LSCPVANMGA QLVKEVASKT ADAAGDGTTT ATVLAYSIFK
110 120 130 140 150
EGLRNITAGA NPIEVKRGMD KAAEAIINEL KKASKKVGGK EEITQVATIS
160 170 180 190 200
ANSDHNIGKL IADAMEKVGK DGVITVEEAK GIEDELDVVE GMQFDRGYLS
210 220 230 240 250
PYFVTNAEKM TAQLDNAYIL LTDKKISSMK DILPLLEKTM KEGKPLLIIA
260 270 280 290 300
EDIEGEALTT LVVNKLRGVL NIAAVKAPGF GDRRKEMLKD IAILTGGQVI
310 320 330 340 350
SEELGLSLEN AEVEFLGKAG RIVIDKDNTT IVDGKGHSDD VKDRVVQIKT
360 370 380 390 400
QIASTTSDYD KEKLQERLAK LSGGVAVIKV GAASEVEMKE KKDRVDDALS
410 420 430 440 450
ATKAAVEEGI VIGGGAALIR AAQKVHLNLH DDEKVGYEII MRAIKAPLAQ
460 470 480 490 500
IAINAGYDGG VVVNEVEKHE GHFGFNASNG KYVDMFKEGI IDPLKVERIA
510 520 530 540
LQNAVSVSSL LLTTEATVHE IKEEKATPAM PDMGGMGGMG GMGGMM
Length:546
Mass (Da):58,300
Last modified:December 16, 2008 - v1
Checksum:i6EA43009F53CB020
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ07168.1.
RefSeqiWP_001040286.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ07168; ACJ07168; HPP12_0008.
KEGGihpp:HPP12_0008.

Similar proteinsi

Entry informationi

Entry nameiCH60_HELP2
AccessioniPrimary (citable) accession number: B6JPA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: November 22, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families