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B6JP37

- NADK_HELP2

UniProt

B6JP37 - NADK_HELP2

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Protein

NAD kinase

Gene

nadK

Organism
Helicobacter pylori (strain P12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton acceptorUniRule annotation
Binding sitei167 – 1671NADUniRule annotation
Binding sitei169 – 1691NADUniRule annotation
Binding sitei177 – 1771NAD; via carbonyl oxygenUniRule annotation
Binding sitei236 – 2361NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi70 – 712NADUniRule annotation
Nucleotide bindingi139 – 1402NADUniRule annotation
Nucleotide bindingi180 – 1856NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-1563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:HPP12_1519
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008198: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284NAD kinasePRO_1000120866Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi570508.HPP12_1519.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiGAEFCLN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B6JP37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDSHQTIGV FVRPTHYQNP LFKELEQAKE WVLKLLEDEG FESFMIDSLD
60 70 80 90 100
GAKDERLIEK ADAFLCLGGD GTILGALRMT HSYNKPCFGV RIGNLGFLSA
110 120 130 140 150
VELNGLKDFL QDLKQDRIKL EEHLALEGRI GNTSFYAINE IVIAKKKALG
160 170 180 190 200
VLDIKAYAGH TPFNTYKGDG LIIATPLGST AYNLSAHGPI VHALSQSYIL
210 220 230 240 250
TPLCDFSLTQ RPLVLGAEFC LNFCTHEDAL VVIDGQSTYD LKANQPLYIQ
260 270 280
KSPTTTKLLQ KNSRDYFKVL KEKLLWGESP SKKR
Length:284
Mass (Da):31,712
Last modified:December 16, 2008 - v1
Checksum:i615A13C4759FEF4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ08665.1.
RefSeqiYP_002302145.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ08665; ACJ08665; HPP12_1519.
GeneIDi7011276.
KEGGihpp:HPP12_1519.
PATRICi20611185. VBIHelPyl2824_1604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ08665.1 .
RefSeqi YP_002302145.1. NC_011498.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 570508.HPP12_1519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ08665 ; ACJ08665 ; HPP12_1519 .
GeneIDi 7011276.
KEGGi hpp:HPP12_1519.
PATRICi 20611185. VBIHelPyl2824_1604.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi GAEFCLN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci HPYL570508:GJ8D-1563-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Helicobacter pylori strain P12."
    Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P12.

Entry informationi

Entry nameiNADK_HELP2
AccessioniPrimary (citable) accession number: B6JP37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3