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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Helicobacter pylori (strain P12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:HPP12_1475
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000008198 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000929461 – 186Peptidyl-tRNA hydrolaseAdd BLAST186

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

SMRiB6JNZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004797.
KOiK01056.
OMAiFNENEEP.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiView protein in InterPro
IPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiView protein in Pfam
PF01195. Pept_tRNA_hydro. 1 hit.
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiView protein in PROSITE
PS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B6JNZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLVGLGNP TLRYAHTRHN AGFDILDSLV SELDLSFTFS SKHNAYLCVY
60 70 80 90 100
KDFILLKPQT YMNLSGESVL SAKNFYKPKE LLIVHDDLDL PLGVVRFKKG
110 120 130 140 150
GGNGGHNGLK SIDLLCSNSY YRLRVGISKG IDVIEHVLSK FHKNEEPLKN
160 170 180
AVFEHAKNAL KFFIESHDFN AMQNRFTLKK PLIIES
Length:186
Mass (Da):21,012
Last modified:December 16, 2008 - v1
Checksum:iD0516A1F3A605AE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ08623.1.
RefSeqiWP_000174006.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ08623; ACJ08623; HPP12_1475.
KEGGihpp:HPP12_1475.
PATRICi20611081. VBIHelPyl2824_1553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ08623.1.
RefSeqiWP_000174006.1. NC_011498.1.

3D structure databases

SMRiB6JNZ5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ08623; ACJ08623; HPP12_1475.
KEGGihpp:HPP12_1475.
PATRICi20611081. VBIHelPyl2824_1553.

Phylogenomic databases

HOGENOMiHOG000004797.
KOiK01056.
OMAiFNENEEP.

Family and domain databases

CDDicd00462. PTH. 1 hit.
Gene3Di3.40.50.1470. 1 hit.
HAMAPiMF_00083. Pept_tRNA_hydro_bact. 1 hit.
InterProiView protein in InterPro
IPR001328. Pept_tRNA_hydro.
IPR018171. Pept_tRNA_hydro_CS.
PANTHERiPTHR17224. PTHR17224. 1 hit.
PfamiView protein in Pfam
PF01195. Pept_tRNA_hydro. 1 hit.
SUPFAMiSSF53178. SSF53178. 1 hit.
TIGRFAMsiTIGR00447. pth. 1 hit.
PROSITEiView protein in PROSITE
PS01195. PEPT_TRNA_HYDROL_1. 1 hit.
PS01196. PEPT_TRNA_HYDROL_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_HELP2
AccessioniPrimary (citable) accession number: B6JNZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: March 15, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.