B6JNP1 (LPXA_HELP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Short name=UDP-N-acetylglucosamine acyltransferase
EC=2.3.1.129

Gene names

Name:	lpxA
Ordered Locus Names:	HPP12_1370

Organism

Helicobacter pylori (strain P12) [Complete proteome] [HAMAP]

Taxonomic identifier

570508 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine. HAMAP-Rule MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP-Rule MF_00387
Subunit structure	Homotrimer By similarity. HAMAP-Rule MF_00387
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP-Rule MF_00387		PRO_1000122710

Sequences

	Sequence		Length	Mass (Da)
	B6JNP1 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: A0C3BA00F5E8EB04	FASTA	270	29,827
	10 20 30 40 50 60 MSKIAKTAII SPKAEINKGV EIGEFCVIGD GVKLDDGVKL HNNVTLQGHT FIGKNTEIFP 70 80 90 100 110 120 FAVLGTQPQD LKYKGEYSEL IVGEDNLIRE FCMINPGTEG GIKKTLIGDK NLLMAYVHVA 130 140 150 160 170 180 HDCVIGSHCI LANGVTLAGH IEIGDYVNIG GLTAIHQFVR IAKGCMIAGK SALGKDVPPY 190 200 210 220 230 240 CTVEGNRAFI RGLNRHRMRQ LLESKDIDFI YALYKRLFRP VPSLRESAKL ELEEHANNPF 250 260 270 VKEICSFILE SSRGVAYKSS EYSSEEKQEE

References

[1]	"The complete genome sequence of Helicobacter pylori strain P12." Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: P12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001217 Genomic DNA. Translation: ACJ08519.1.
RefSeq	YP_002301999.1. NC_011498.1.
3D structure databases
ProteinModelPortal	B6JNP1.
ModBase	Search...
Protein-protein interaction databases
STRING	570508.HPP12_1370.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACJ08519; ACJ08519; HPP12_1370.
GeneID	7011123.
KEGG	hpp:HPP12_1370.
PATRIC	20610853. VBIHelPyl2824_1441.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1043.
HOGENOM	HOG000294326.
KO	K00677.
OMA	GDKNLLM.
ProtClustDB	PRK05289.
Enzyme and pathway databases
BioCyc	HPYL570508:GJ8D-1410-MONOMER.
UniPathway	UPA00359; UER00477.
Family and domain databases
HAMAP	MF_00387. LpxA.
InterPro	IPR001451. Hexapep_transf. IPR010137. Lipid_A_LpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXA_HELP2

Accession

Primary (citable) accession number: B6JNP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	December 16, 2008
Last modified:	May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program