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B6JN53

- PNP_HELP2

UniProt

B6JN53 - PNP_HELP2

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Helicobacter pylori (strain P12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841MagnesiumUniRule annotation
Metal bindingi490 – 4901MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-1219-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:HPP12_1179
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008198: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 688688Polyribonucleotide nucleotidyltransferasePRO_0000381902Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi570508.HPP12_1179.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini550 – 60960KHUniRule annotationAdd
BLAST
Domaini626 – 68863S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6JN53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFITINSSN KTEEFALKQV AKQATSSLMY RLGKTIILAS VCVEREPVSE
60 70 80 90 100
DFLPLVVQFL EKSYAAGKIP GGFVKREGRA QDFEILTSRL IDRTLRPLFP
110 120 130 140 150
KDYRYPTQIT LMVLSHDIEN DLQVSALNAA SAALFLAHIA PIKSVSACRI
160 170 180 190 200
ARIDNEFIIN PNTSLLNQSS LDLFVSGTKE SLNMIEMRSL GQKLNALEEP
210 220 230 240 250
LMLEALELAQ KSLKETCTLY EEVFTPHQNE LLFKESQAIV LNERLLDLLT
260 270 280 290 300
NQYFDEIIKG IESSALSERE NVFNEIAKKI SEAHSEFSLE EIEWSLEKVK
310 320 330 340 350
KTEIRRMIIQ DKIRPDKRAL EEVRPILIES DLLPMAHSSI LFTRGQTQSL
360 370 380 390 400
VVGVLGTDND AQTHESLEHK TPIKERFMFH YNFPPFCVGE ASSIGAASRR
410 420 430 440 450
ELGHGNLAKR ALETSIKNKE QVIRLVSEIL ESNGSSSMAS VCAGSLALYA
460 470 480 490 500
SGVEIYDLVA GVAMGMVSEG QDHAILSDIS GLEDAEGDMD FKIAGNLEGI
510 520 530 540 550
TAMQMDTKMS GIKLEILYQA LLQAKEAREH ILKIMHEAKE KIVINFSHLP
560 570 580 590 600
TTEIFNVAPD KIVEIIGQGG RVIKEIVEKF EVKIDLNKPS GEVKIMGNKE
610 620 630 640 650
RVLKTKEFIL NYLHSLDQEL EQYAIDEVLE AQVKRIVDFG AFLSLPKGGE
660 670 680
GLLRKQNMDR CQVVLKEGDS IKCRVISFNK GKIALDLA
Length:688
Mass (Da):76,932
Last modified:December 16, 2008 - v1
Checksum:i995244476033A4E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001217 Genomic DNA. Translation: ACJ08331.1.
RefSeqiWP_000345852.1. NC_011498.1.
YP_002301811.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ08331; ACJ08331; HPP12_1179.
GeneIDi7010339.
KEGGihpp:HPP12_1179.
PATRICi20610446. VBIHelPyl2824_1238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001217 Genomic DNA. Translation: ACJ08331.1 .
RefSeqi WP_000345852.1. NC_011498.1.
YP_002301811.1. NC_011498.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 570508.HPP12_1179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ08331 ; ACJ08331 ; HPP12_1179 .
GeneIDi 7010339.
KEGGi hpp:HPP12_1179.
PATRICi 20610446. VBIHelPyl2824_1238.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci HPYL570508:GJ8D-1219-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Helicobacter pylori strain P12."
    Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P12.

Entry informationi

Entry nameiPNP_HELP2
AccessioniPrimary (citable) accession number: B6JN53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3