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B6JMU0 (B6JMU0_HELP2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966

Short name=G6PD HAMAP-Rule MF_00966
EC=1.1.1.49 HAMAP-Rule MF_00966
Gene names
Name:zwf HAMAP-Rule MF_00966
Ordered Locus Names:HPP12_1066 EMBL ACJ08218.1
OrganismHelicobacter pylori (strain P12) [Complete proteome] [HAMAP] EMBL ACJ08218.1
Taxonomic identifier570508 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. RuleBase RU000497 HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. RuleBase RU000497 HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family. RuleBase RU000497 HAMAP-Rule MF_00966

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2251Proton acceptor By similarity HAMAP-Rule MF_00966
Binding site441NADP By similarity HAMAP-Rule MF_00966
Binding site1351NADP By similarity HAMAP-Rule MF_00966
Binding site1651Substrate By similarity HAMAP-Rule MF_00966
Binding site1691Substrate By similarity HAMAP-Rule MF_00966
Binding site2011Substrate By similarity HAMAP-Rule MF_00966
Binding site2201Substrate By similarity HAMAP-Rule MF_00966
Binding site3111Substrate By similarity HAMAP-Rule MF_00966

Sequences

Sequence LengthMass (Da)Tools
B6JMU0 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: CB3359DF9103496D

FASTA42549,359
        10         20         30         40         50         60 
MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE EFLALLCEKT 

        70         80         90        100        110        120 
QLHSREKGEE FLAHISYLCV RLDNPKDFEE LSKIATKNKP LIFYFSISPS FFATTAQNLA 

       130        140        150        160        170        180 
QNALNHANTR LILEKPLGHD LKTCKEIFQS ISAFFKEEQI FRIDHYLGKK GVQNILELRL 

       190        200        210        220        230        240 
NNPILNILWD QISAVEICVY ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND 

       250        260        270        280        290        300 
LKDLRKEKIK VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 

       310        320        330        340        350        360 
KGVPFYLKHA KKMPHNQASV KIHFNATNTL EFFLSQDKIT LTLKDHQNPL ILETHNQQEF 

       370        380        390        400        410        420 
LQPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM NNATPLHSYE SHNLNESEFL 


KPLYQ 

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References

[1]"The complete genome sequence of Helicobacter pylori strain P12."
Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: P12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001217 Genomic DNA. Translation: ACJ08218.1.
RefSeqYP_002301698.1. NC_011498.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING570508.HPP12_1066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ08218; ACJ08218; HPP12_1066.
GeneID7010217.
KEGGhpp:HPP12_1066.
PATRIC20610186. VBIHelPyl2824_1117.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046191.
KOK00036.
OMAEREWRNT.
OrthoDBEOG61308Z.

Enzyme and pathway databases

BioCycHPYL570508:GJ8D-1097-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB6JMU0_HELP2
AccessionPrimary (citable) accession number: B6JMU0
Entry history
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)