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B6JMU0

- B6JMU0_HELP2

UniProt

B6JMU0 - B6JMU0_HELP2

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, HPP12_1066
Organism
Helicobacter pylori (strain P12)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADP By similarityUniRule annotation
Binding sitei135 – 1351NADP By similarityUniRule annotation
Binding sitei165 – 1651Substrate By similarityUniRule annotation
Binding sitei169 – 1691Substrate By similarityUniRule annotation
Binding sitei201 – 2011Substrate By similarityUniRule annotation
Binding sitei220 – 2201Substrate By similarityUniRule annotation
Active sitei225 – 2251Proton acceptor By similarityUniRule annotation
Binding sitei311 – 3111Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-1097-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:HPP12_1066Imported
OrganismiHelicobacter pylori (strain P12)Imported
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008198: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi570508.HPP12_1066.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiEREWRNT.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6JMU0-1 [UniParc]FASTAAdd to Basket

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MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE    50
EFLALLCEKT QLHSREKGEE FLAHISYLCV RLDNPKDFEE LSKIATKNKP 100
LIFYFSISPS FFATTAQNLA QNALNHANTR LILEKPLGHD LKTCKEIFQS 150
ISAFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY 200
ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND LKDLRKEKIK 250
VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 300
KGVPFYLKHA KKMPHNQASV KIHFNATNTL EFFLSQDKIT LTLKDHQNPL 350
ILETHNQQEF LQPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM 400
NNATPLHSYE SHNLNESEFL KPLYQ 425
Length:425
Mass (Da):49,359
Last modified:December 16, 2008 - v1
Checksum:iCB3359DF9103496D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001217 Genomic DNA. Translation: ACJ08218.1.
RefSeqiYP_002301698.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ08218; ACJ08218; HPP12_1066.
GeneIDi7010217.
KEGGihpp:HPP12_1066.
PATRICi20610186. VBIHelPyl2824_1117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001217 Genomic DNA. Translation: ACJ08218.1 .
RefSeqi YP_002301698.1. NC_011498.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 570508.HPP12_1066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ08218 ; ACJ08218 ; HPP12_1066 .
GeneIDi 7010217.
KEGGi hpp:HPP12_1066.
PATRICi 20610186. VBIHelPyl2824_1117.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi EREWRNT.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci HPYL570508:GJ8D-1097-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Helicobacter pylori strain P12."
    Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P12.

Entry informationi

Entry nameiB6JMU0_HELP2
AccessioniPrimary (citable) accession number: B6JMU0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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