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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Helicobacter pylori (strain P12)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44NADPUniRule annotation1
Binding sitei135NADPUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Binding sitei201SubstrateUniRule annotation1
Binding sitei220SubstrateUniRule annotation1
Active sitei225Proton acceptorUniRule annotation1
Binding sitei311SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:HPP12_1066Imported
OrganismiHelicobacter pylori (strain P12)Imported
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000008198 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 174G6PD_NInterPro annotationAdd BLAST168
Domaini177 – 413G6PD_CInterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046191.
KOiK00036.
OMAiVEICVYE.

Family and domain databases

HAMAPiMF_00966. G6PD. 1 hit.
InterProiView protein in InterPro
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiView protein in Pfam
PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PIRSFiPIRSF000110. G6PD. 2 hits.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00069. G6P_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

B6JMU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE
60 70 80 90 100
EFLALLCEKT QLHSREKGEE FLAHISYLCV RLDNPKDFEE LSKIATKNKP
110 120 130 140 150
LIFYFSISPS FFATTAQNLA QNALNHANTR LILEKPLGHD LKTCKEIFQS
160 170 180 190 200
ISAFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY
210 220 230 240 250
ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND LKDLRKEKIK
260 270 280 290 300
VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF
310 320 330 340 350
KGVPFYLKHA KKMPHNQASV KIHFNATNTL EFFLSQDKIT LTLKDHQNPL
360 370 380 390 400
ILETHNQQEF LQPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM
410 420
NNATPLHSYE SHNLNESEFL KPLYQ
Length:425
Mass (Da):49,359
Last modified:December 16, 2008 - v1
Checksum:iCB3359DF9103496D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ08218.1.
RefSeqiWP_000883615.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ08218; ACJ08218; HPP12_1066.
KEGGihpp:HPP12_1066.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB6JMU0_HELP2
AccessioniPrimary (citable) accession number: B6JMU0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported