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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Helicobacter pylori (strain P12)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADPUniRule annotation
Binding sitei135 – 1351NADPUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei220 – 2201SubstrateUniRule annotation
Active sitei225 – 2251Proton acceptorUniRule annotation
Binding sitei311 – 3111SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-1097-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:HPP12_1066Imported
OrganismiHelicobacter pylori (strain P12)Imported
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008198: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi570508.HPP12_1066.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiGEEFLAH.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6JMU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE
60 70 80 90 100
EFLALLCEKT QLHSREKGEE FLAHISYLCV RLDNPKDFEE LSKIATKNKP
110 120 130 140 150
LIFYFSISPS FFATTAQNLA QNALNHANTR LILEKPLGHD LKTCKEIFQS
160 170 180 190 200
ISAFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY
210 220 230 240 250
ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND LKDLRKEKIK
260 270 280 290 300
VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF
310 320 330 340 350
KGVPFYLKHA KKMPHNQASV KIHFNATNTL EFFLSQDKIT LTLKDHQNPL
360 370 380 390 400
ILETHNQQEF LQPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM
410 420
NNATPLHSYE SHNLNESEFL KPLYQ
Length:425
Mass (Da):49,359
Last modified:December 16, 2008 - v1
Checksum:iCB3359DF9103496D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ08218.1.
RefSeqiYP_002301698.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ08218; ACJ08218; HPP12_1066.
GeneIDi7010217.
KEGGihpp:HPP12_1066.
PATRICi20610186. VBIHelPyl2824_1117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ08218.1.
RefSeqiYP_002301698.1. NC_011498.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi570508.HPP12_1066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ08218; ACJ08218; HPP12_1066.
GeneIDi7010217.
KEGGihpp:HPP12_1066.
PATRICi20610186. VBIHelPyl2824_1117.

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiGEEFLAH.
OrthoDBiEOG61308Z.

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-1097-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 2 hits.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Helicobacter pylori strain P12."
    Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P12Imported.

Entry informationi

Entry nameiB6JMU0_HELP2
AccessioniPrimary (citable) accession number: B6JMU0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: March 4, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.