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B6JMU0

- B6JMU0_HELP2

UniProt

B6JMU0 - B6JMU0_HELP2

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Helicobacter pylori (strain P12)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441NADPUniRule annotation
    Binding sitei135 – 1351NADPUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Binding sitei169 – 1691SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Binding sitei220 – 2201SubstrateUniRule annotation
    Active sitei225 – 2251Proton acceptorUniRule annotation
    Binding sitei311 – 3111SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciHPYL570508:GJ8D-1097-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:HPP12_1066Imported
    OrganismiHelicobacter pylori (strain P12)Imported
    Taxonomic identifieri570508 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008198: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi570508.HPP12_1066.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiEREWRNT.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 2 hits.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6JMU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDFDLVLFG ATGDLAMRKL FVSLYEIYTH YGFKNDSRII ASGRKELSNE    50
    EFLALLCEKT QLHSREKGEE FLAHISYLCV RLDNPKDFEE LSKIATKNKP 100
    LIFYFSISPS FFATTAQNLA QNALNHANTR LILEKPLGHD LKTCKEIFQS 150
    ISAFFKEEQI FRIDHYLGKK GVQNILELRL NNPILNILWD QISAVEICVY 200
    ETLGVEERGE FYDKIGALRD MVQNHLLQVL SLIATDLPND LKDLRKEKIK 250
    VLKTLQPPKD FKKQVIRAQY QGYRDENKVH KESQTETFVA IKAFLDTPKF 300
    KGVPFYLKHA KKMPHNQASV KIHFNATNTL EFFLSQDKIT LTLKDHQNPL 350
    ILETHNQQEF LQPYAKLLYD AIQNNHNNFA HQLELEASWV FIDTLIEGFM 400
    NNATPLHSYE SHNLNESEFL KPLYQ 425
    Length:425
    Mass (Da):49,359
    Last modified:December 16, 2008 - v1
    Checksum:iCB3359DF9103496D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001217 Genomic DNA. Translation: ACJ08218.1.
    RefSeqiYP_002301698.1. NC_011498.1.

    Genome annotation databases

    EnsemblBacteriaiACJ08218; ACJ08218; HPP12_1066.
    GeneIDi7010217.
    KEGGihpp:HPP12_1066.
    PATRICi20610186. VBIHelPyl2824_1117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001217 Genomic DNA. Translation: ACJ08218.1 .
    RefSeqi YP_002301698.1. NC_011498.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 570508.HPP12_1066.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ08218 ; ACJ08218 ; HPP12_1066 .
    GeneIDi 7010217.
    KEGGi hpp:HPP12_1066.
    PATRICi 20610186. VBIHelPyl2824_1117.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi EREWRNT.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci HPYL570508:GJ8D-1097-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 2 hits.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Helicobacter pylori strain P12."
      Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P12Imported.

    Entry informationi

    Entry nameiB6JMU0_HELP2
    AccessioniPrimary (citable) accession number: B6JMU0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 16, 2008
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3