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B6JM91

- LPXB_HELP2

UniProt

B6JM91 - LPXB_HELP2

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, HPP12_0867
Organism
Helicobacter pylori (strain P12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-883-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:HPP12_0867
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008198: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Lipid-A-disaccharide synthaseUniRule annotationPRO_1000123051Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi570508.HPP12_0867.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B6JM91-1 [UniParc]FASTAAdd to Basket

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MPTILVSALE ASSNVHLEEL RHNLPKDYRF IGVFEGKNAL YSPREFSVMG    50
FRDVIGRLGF LLKAHKEMVQ LAKQADMVLL MDSSSFNIPL AKKIKKQDPH 100
KKIMYYILPQ VWAWKKWRAK SLEKYCDFLG AILPFEVGYY QKKAQYVGHP 150
LLDEIKYYKK DIKGETLVFM PGSRKSEIAK MFPLFVKAAQ ILEQNEGFKR 200
RVLVVPSFFK GLDLKALYGE DIKLFEISYD AHKSLFEAEF AFICSGTATL 250
EAALIGTPFV LAYRAKTMDF LIARMLVNLH YIGLANIFYN ALNNETPGLG 300
ESQLHPELIQ HFLSVEGLLK AYEEMDRERY FKESLRLREY LASGSTRKIA 350
NEMAFLLNLT 360
Length:360
Mass (Da):41,429
Last modified:December 16, 2008 - v1
Checksum:i519F236AB9E11C03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001217 Genomic DNA. Translation: ACJ08019.1.
RefSeqiYP_002301499.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ08019; ACJ08019; HPP12_0867.
GeneIDi7010003.
KEGGihpp:HPP12_0867.
PATRICi20609739. VBIHelPyl2824_0908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001217 Genomic DNA. Translation: ACJ08019.1 .
RefSeqi YP_002301499.1. NC_011498.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 570508.HPP12_0867.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ08019 ; ACJ08019 ; HPP12_0867 .
GeneIDi 7010003.
KEGGi hpp:HPP12_0867.
PATRICi 20609739. VBIHelPyl2824_0908.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci HPYL570508:GJ8D-883-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Helicobacter pylori strain P12."
    Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P12.

Entry informationi

Entry nameiLPXB_HELP2
AccessioniPrimary (citable) accession number: B6JM91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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