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B6JM38 (ACPS_HELP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Holo-[acyl-carrier-protein] synthase

Short name=Holo-ACP synthase
EC=2.7.8.7
Alternative name(s):
4'-phosphopantetheinyl transferase AcpS
Gene names
Name:acpS
Ordered Locus Names:HPP12_0814
OrganismHelicobacter pylori (strain P12) [Complete proteome] [HAMAP]
Taxonomic identifier570508 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP-Rule MF_00101

Catalytic activity

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP-Rule MF_00101

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00101

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00101.

Sequence similarities

Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

macromolecule biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionholo-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 118118Holo-[acyl-carrier-protein] synthase HAMAP-Rule MF_00101
PRO_1000093880

Sites

Metal binding51Magnesium By similarity
Metal binding511Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
B6JM38 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: C26069E10EC3CF4B

FASTA11813,009
        10         20         30         40         50         60 
MIGVDIVSIA RIEKCVKRFE MRFLERFLSP SEIVLCKDKF SSIAGFFALK EACSKALQVG 

        70         80         90        100        110 
IGKELSFLDM HISKSPKNAP LITLSKEKMD YFNIQSLSAS ISHDAGFAIA VVMVSSSN 

« Hide

References

[1]"The complete genome sequence of Helicobacter pylori strain P12."
Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: P12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001217 Genomic DNA. Translation: ACJ07966.1.
RefSeqYP_002301446.1. NC_011498.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING570508.HPP12_0814.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ07966; ACJ07966; HPP12_0814.
GeneID7009949.
KEGGhpp:HPP12_0814.
PATRIC20609625. VBIHelPyl2824_0852.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0736.
HOGENOMHOG000014315.
KOK00997.
OMAIARIEKC.
OrthoDBEOG6384R9.

Enzyme and pathway databases

BioCycHPYL570508:GJ8D-829-MONOMER.

Family and domain databases

Gene3D3.90.470.20. 1 hit.
HAMAPMF_00101. AcpS.
InterProIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase_dom.
[Graphical view]
PfamPF01648. ACPS. 1 hit.
[Graphical view]
ProDomPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56214. SSF56214. 1 hit.
TIGRFAMsTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACPS_HELP2
AccessionPrimary (citable) accession number: B6JM38
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families