B6JM38 (ACPS_HELP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS

Gene names

Name:	acpS
Ordered Locus Names:	HPP12_0814

Organism

Helicobacter pylori (strain P12) [Complete proteome] [HAMAP]

Taxonomic identifier

570508 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP-Rule MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP-Rule MF_00101
Cofactor	Magnesium By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 118	118	Holo-[acyl-carrier-protein] synthase HAMAP-Rule MF_00101		PRO_1000093880
Sites
	Metal binding	5	1	Magnesium By similarity
	Metal binding	51	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6JM38 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: C26069E10EC3CF4B	FASTA	118	13,009
	10 20 30 40 50 60 MIGVDIVSIA RIEKCVKRFE MRFLERFLSP SEIVLCKDKF SSIAGFFALK EACSKALQVG 70 80 90 100 110 IGKELSFLDM HISKSPKNAP LITLSKEKMD YFNIQSLSAS ISHDAGFAIA VVMVSSSN

References

[1]	"The complete genome sequence of Helicobacter pylori strain P12." Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: P12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001217 Genomic DNA. Translation: ACJ07966.1.
RefSeq	YP_002301446.1. NC_011498.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	570508.HPP12_0814.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACJ07966; ACJ07966; HPP12_0814.
GeneID	7009949.
KEGG	hpp:HPP12_0814.
PATRIC	20609625. VBIHelPyl2824_0852.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0736.
HOGENOM	HOG000014315.
KO	K00997.
OMA	IARIEKC.
ProtClustDB	PRK00070.
Enzyme and pathway databases
BioCyc	HPYL570508:GJ8D-829-MONOMER.
Family and domain databases
Gene3D	3.90.470.20. 1 hit.
HAMAP	MF_00101. AcpS.
InterPro	IPR008278. 4-PPantetheinyl_Trfase_SF. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase_dom. [Graphical view]
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. acpS. 1 hit. TIGR00556. pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACPS_HELP2

Accession

Primary (citable) accession number: B6JM38

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program