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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Helicobacter pylori (strain P12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi288Magnesium or manganese 1UniRule annotation1
Metal bindingi300Magnesium or manganese 1UniRule annotation1
Metal bindingi300Magnesium or manganese 2UniRule annotation1
Metal bindingi302Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi161 – 216ATPUniRule annotationAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL570508:G1GU0-780-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:HPP12_0747
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000008198 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000911851 – 347D-alanine--D-alanine ligaseAdd BLAST347

Structurei

3D structure databases

ProteinModelPortaliB6JLX1
SMRiB6JLX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 332ATP-graspUniRule annotationAdd BLAST199

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000102494
KOiK01921
OMAiRCDFFVI

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B6JLX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFCVLFGGA SFEHEISIVS AIALKEVLKD RIKHFIFLDE NHHFYLIEAS
60 70 80 90 100
NMHSKYFAQI KEKKLPPLIL AHNGLLKNSF LGTKIIELPL VINLVHGGDG
110 120 130 140 150
EDGKLASLLE FYRIAFIGPR IEASVLSYNK YLTKLYAKDL GVKTLDYVLL
160 170 180 190 200
NEKNRANALD LIKFNFPFIV KPSNAGSSLG VNVVKEEKEL VYALDSAFEY
210 220 230 240 250
SKEVLIEPFI QGVKEYNLAG CKIKTDFCFS YIEEPNKQEF LDFKQKYLDF
260 270 280 290 300
SRNKAPKANL SNALEEQLKE NFKKLYNDLF SGAIIRCDFF VIENEVYLNE
310 320 330 340
INPIPGSLAH YLFDDFKTTL ENLAQSLPKT PKIQVKNSYL LQIQKNK
Length:347
Mass (Da):39,704
Last modified:December 16, 2008 - v1
Checksum:i6DC8B3F322C11720
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA Translation: ACJ07899.1
RefSeqiWP_000393634.1, NC_011498.1

Genome annotation databases

EnsemblBacteriaiACJ07899; ACJ07899; HPP12_0747
KEGGihpp:HPP12_0747

Similar proteinsi

Entry informationi

Entry nameiDDL_HELP2
AccessioniPrimary (citable) accession number: B6JLX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health