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B6JKX8 (ACSA_HELP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene names
Name:acsA
Ordered Locus Names:HPP12_0399
OrganismHelicobacter pylori (strain P12) [Complete proteome] [HAMAP]
Taxonomic identifier570508 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 662662Acetyl-coenzyme A synthetase HAMAP MF_01123
PRO_1000137264

Sites

Active site5271 By similarity

Amino acid modifications

Modified residue6231N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B6JKX8 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: CCCD6040C18DE35C

FASTA66275,044
        10         20         30         40         50         60 
MQLDEDLEFA KKIFNPNRAF AKQARIKNMC EYKDLVHEAN EDYEHFWGEL AKQKLTWFKP 

        70         80         90        100        110        120 
FDKVLNSDNA PFFKWFENGK INVSYNCIDR HLKDKKNKVA IIFEGEMGDY NVITYRKLHS 

       130        140        150        160        170        180 
EVNKTANLLK NEFNVKKGDR VIIYMPMIVE SVYMMLACAR IGAIHSIVFA GFSPEALRDR 

       190        200        210        220        230        240 
INDAQAKLVI TADGTFRKGK PYMLKPALDK ALENNACPSV EKALIVIRNA REIDYVRGRD 

       250        260        270        280        290        300 
FVYNEMVNYQ SDKCEPEMMD SEDPLFLLYT SGSTGKPKGV QHSSAGYLLW AQMTMEWVFD 

       310        320        330        340        350        360 
IRDNDNFWCT ADIGWITGHT YVVYGPLACG ATTLILEGTM SYPDYGRWWR MIEEYRVDKF 

       370        380        390        400        410        420 
YTSPTAIRML HAKGENEPLK YNLESLKVLG TVGEPINPTA WKWFYEKIGN SKCSIVDTWW 

       430        440        450        460        470        480 
QTETGGHIIS PLPGATPIRA SCATLPLPGI HAEVLNEDGT KTKPGEQGFL CITKPWPSMV 

       490        500        510        520        530        540 
RNIWGDEKRY IDSYFSQIKL NGEYVYLSGD GAIVDENGYI TIIGRTDDIV NVSGHRIGTA 

       550        560        570        580        590        600 
EVESAISKHE MVVECAVVGI PDTIKGEGLF AFVVLCDGAK CNLGESLELL KEMNHILSVE 

       610        620        630        640        650        660 
IGKIAKLDNV MYVPGLPKTR SGKIMRRLLK SIAKKEPITQ DLSTLEDVNV VKEIMSIVQM 


EE

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References

[1]"The complete genome sequence of Helicobacter pylori strain P12."
Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: P12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001217 Genomic DNA. Translation: ACJ07556.1.
RefSeqYP_002301036.1. NC_011498.1.

3D structure databases

ProteinModelPortalB6JKX8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB6JKX8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7010773.
GenomeReviewsGene locus HPP12_0399 in contig CP001217_GR.
KEGGhpp:HPP12_0399.
PATRIC20608760. VBIHelPyl2824_0421.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG547964.
OMAKGKPYML.
ProtClustDBPRK00174.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA_HELP2
AccessionPrimary (citable) accession number: B6JKX8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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