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B6JKX5 (IF2_HELP2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:HPP12_0396
OrganismHelicobacter pylori (strain P12) [Complete proteome] [HAMAP]
Taxonomic identifier570508 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length947 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 947947Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000093791

Regions

Nucleotide binding455 – 4628GTP By similarity
Nucleotide binding501 – 5055GTP By similarity
Nucleotide binding555 – 5584GTP By similarity
Region449 – 597149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
B6JKX5 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: FE2C4C36621F1DC4

FASTA947105,682
        10         20         30         40         50         60 
MSEMVDLKEF LAELGKTQKE LKNVIEQAKD IGLELKTNSK MTPEQAGKLY KYIVDGIKEQ 

        70         80         90        100        110        120 
IQANQPAKNP EQDNKDDLNT AVASKSLNKK VFKTPKKEET KSQPKPKKTK EKKKEAPTPI 

       130        140        150        160        170        180 
AKKKGGIEIV NTFEDQTPPV ENAPKVVSHS QIEKAKQKLQ EIQKSREALN KLTQSNANNA 

       190        200        210        220        230        240 
NSTNNANNAK KEISEVKKQE QEIKRHENIK RRTGFRVIKR NDETENETEN SVTESKKPTQ 

       250        260        270        280        290        300 
SAAAIFEDIK KEWQEKDKQE AKKVKKPSKP KATPTAKNNK SHKIDFSDAR DFKGNDIYDD 

       310        320        330        340        350        360 
ETDEILLFDL HEQDNLNKEE EEKEIRQNIN DRVRVQRKNP WMNESGIKRQ SKKKRAFRND 

       370        380        390        400        410        420 
NSQKVIQSAI AIPEEVRVYE FAQKANLNLA DVIKTLFNLG LMVTKNDFLD KDSIEILAEE 

       430        440        450        460        470        480 
FHLEISVQNT LEEFEVEEVL EGVKKERPPV VTIMGHVDHG KTSLLDKIRD KRVAHTEAGG 

       490        500        510        520        530        540 
ITQHIGAYMV EKNNKWVSFI DTPGHEAFSQ MRNRGAQVTD IAVIVIAADD GVKQQTIEAL 

       550        560        570        580        590        600 
EHAKAANVPV IFAMNKMDKP NVNPDKLKAE CAELGYNPVD WGGEHEFIPV SAKTGDGIDN 

       610        620        630        640        650        660 
LLETILIQAD IMELKAIEEG SARAVVLEGS VEKGRGAVAT VIVQSGTLSV GDSFFAETAF 

       670        680        690        700        710        720 
GKVRTMTDDQ GKSIQNLKPS MVALITGLSE VPPAGSVLIG VENDSIARLQ AQKRATYLHQ 

       730        740        750        760        770        780 
KALSKSTKVS FDELSEMVAN KELKNIPVVI KADTQGSLEA IKNSLLELNN EEVAIQVIHS 

       790        800        810        820        830        840 
GVGGITENDL SLVSNSEHAV ILGFNIRPTG NVKNKAKEYN VSIKTYTVIY ALIEEMRSLL 

       850        860        870        880        890        900 
LGLMSPIIEE EHTGQAEVRE TFNIPKVGTI AGCVVSDGVI ARGIKARLIR DGVVIHTGEI 

       910        920        930        940 
LSLKRFKDDV KEVSKGYECG IMLDNYNEIK VGDVFETYKE IHKKRTL 

« Hide

References

[1]"The complete genome sequence of Helicobacter pylori strain P12."
Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: P12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001217 Genomic DNA. Translation: ACJ07553.1.
RefSeqYP_002301033.1. NC_011498.1.

3D structure databases

ProteinModelPortalB6JKX5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING570508.HPP12_0396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ07553; ACJ07553; HPP12_0396.
GeneID7010770.
KEGGhpp:HPP12_0396.
PATRIC20608754. VBIHelPyl2824_0418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMAIQRPTHI.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycHPYL570508:GJ8D-409-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_HELP2
AccessionPrimary (citable) accession number: B6JKX5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries