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B6JKX5

- IF2_HELP2

UniProt

B6JKX5 - IF2_HELP2

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Helicobacter pylori (strain P12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi455 – 4628GTPUniRule annotation
    Nucleotide bindingi501 – 5055GTPUniRule annotation
    Nucleotide bindingi555 – 5584GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPYL570508:GJ8D-409-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:HPP12_0396
    OrganismiHelicobacter pylori (strain P12)
    Taxonomic identifieri570508 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000008198: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 947947Translation initiation factor IF-2PRO_1000093791Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi570508.HPP12_0396.

    Structurei

    3D structure databases

    ProteinModelPortaliB6JKX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini446 – 615170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni455 – 4628G1By similarity
    Regioni480 – 4845G2By similarity
    Regioni501 – 5044G3By similarity
    Regioni555 – 5584G4By similarity
    Regioni591 – 5933G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiEHEFIPV.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6JKX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEMVDLKEF LAELGKTQKE LKNVIEQAKD IGLELKTNSK MTPEQAGKLY    50
    KYIVDGIKEQ IQANQPAKNP EQDNKDDLNT AVASKSLNKK VFKTPKKEET 100
    KSQPKPKKTK EKKKEAPTPI AKKKGGIEIV NTFEDQTPPV ENAPKVVSHS 150
    QIEKAKQKLQ EIQKSREALN KLTQSNANNA NSTNNANNAK KEISEVKKQE 200
    QEIKRHENIK RRTGFRVIKR NDETENETEN SVTESKKPTQ SAAAIFEDIK 250
    KEWQEKDKQE AKKVKKPSKP KATPTAKNNK SHKIDFSDAR DFKGNDIYDD 300
    ETDEILLFDL HEQDNLNKEE EEKEIRQNIN DRVRVQRKNP WMNESGIKRQ 350
    SKKKRAFRND NSQKVIQSAI AIPEEVRVYE FAQKANLNLA DVIKTLFNLG 400
    LMVTKNDFLD KDSIEILAEE FHLEISVQNT LEEFEVEEVL EGVKKERPPV 450
    VTIMGHVDHG KTSLLDKIRD KRVAHTEAGG ITQHIGAYMV EKNNKWVSFI 500
    DTPGHEAFSQ MRNRGAQVTD IAVIVIAADD GVKQQTIEAL EHAKAANVPV 550
    IFAMNKMDKP NVNPDKLKAE CAELGYNPVD WGGEHEFIPV SAKTGDGIDN 600
    LLETILIQAD IMELKAIEEG SARAVVLEGS VEKGRGAVAT VIVQSGTLSV 650
    GDSFFAETAF GKVRTMTDDQ GKSIQNLKPS MVALITGLSE VPPAGSVLIG 700
    VENDSIARLQ AQKRATYLHQ KALSKSTKVS FDELSEMVAN KELKNIPVVI 750
    KADTQGSLEA IKNSLLELNN EEVAIQVIHS GVGGITENDL SLVSNSEHAV 800
    ILGFNIRPTG NVKNKAKEYN VSIKTYTVIY ALIEEMRSLL LGLMSPIIEE 850
    EHTGQAEVRE TFNIPKVGTI AGCVVSDGVI ARGIKARLIR DGVVIHTGEI 900
    LSLKRFKDDV KEVSKGYECG IMLDNYNEIK VGDVFETYKE IHKKRTL 947
    Length:947
    Mass (Da):105,682
    Last modified:December 16, 2008 - v1
    Checksum:iFE2C4C36621F1DC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001217 Genomic DNA. Translation: ACJ07553.1.
    RefSeqiYP_002301033.1. NC_011498.1.

    Genome annotation databases

    EnsemblBacteriaiACJ07553; ACJ07553; HPP12_0396.
    GeneIDi7010770.
    KEGGihpp:HPP12_0396.
    PATRICi20608754. VBIHelPyl2824_0418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001217 Genomic DNA. Translation: ACJ07553.1 .
    RefSeqi YP_002301033.1. NC_011498.1.

    3D structure databases

    ProteinModelPortali B6JKX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 570508.HPP12_0396.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ07553 ; ACJ07553 ; HPP12_0396 .
    GeneIDi 7010770.
    KEGGi hpp:HPP12_0396.
    PATRICi 20608754. VBIHelPyl2824_0418.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi EHEFIPV.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci HPYL570508:GJ8D-409-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Helicobacter pylori strain P12."
      Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P12.

    Entry informationi

    Entry nameiIF2_HELP2
    AccessioniPrimary (citable) accession number: B6JKX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3