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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Helicobacter pylori (strain P12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi455 – 4628GTPUniRule annotation
Nucleotide bindingi501 – 5055GTPUniRule annotation
Nucleotide bindingi555 – 5584GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-409-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:HPP12_0396
OrganismiHelicobacter pylori (strain P12)
Taxonomic identifieri570508 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000008198: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 947947Translation initiation factor IF-2PRO_1000093791Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi570508.HPP12_0396.

Structurei

3D structure databases

ProteinModelPortaliB6JKX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini446 – 615170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni455 – 4628G1By similarity
Regioni480 – 4845G2By similarity
Regioni501 – 5044G3By similarity
Regioni555 – 5584G4By similarity
Regioni591 – 5933G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiANQPAKN.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6JKX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEMVDLKEF LAELGKTQKE LKNVIEQAKD IGLELKTNSK MTPEQAGKLY
60 70 80 90 100
KYIVDGIKEQ IQANQPAKNP EQDNKDDLNT AVASKSLNKK VFKTPKKEET
110 120 130 140 150
KSQPKPKKTK EKKKEAPTPI AKKKGGIEIV NTFEDQTPPV ENAPKVVSHS
160 170 180 190 200
QIEKAKQKLQ EIQKSREALN KLTQSNANNA NSTNNANNAK KEISEVKKQE
210 220 230 240 250
QEIKRHENIK RRTGFRVIKR NDETENETEN SVTESKKPTQ SAAAIFEDIK
260 270 280 290 300
KEWQEKDKQE AKKVKKPSKP KATPTAKNNK SHKIDFSDAR DFKGNDIYDD
310 320 330 340 350
ETDEILLFDL HEQDNLNKEE EEKEIRQNIN DRVRVQRKNP WMNESGIKRQ
360 370 380 390 400
SKKKRAFRND NSQKVIQSAI AIPEEVRVYE FAQKANLNLA DVIKTLFNLG
410 420 430 440 450
LMVTKNDFLD KDSIEILAEE FHLEISVQNT LEEFEVEEVL EGVKKERPPV
460 470 480 490 500
VTIMGHVDHG KTSLLDKIRD KRVAHTEAGG ITQHIGAYMV EKNNKWVSFI
510 520 530 540 550
DTPGHEAFSQ MRNRGAQVTD IAVIVIAADD GVKQQTIEAL EHAKAANVPV
560 570 580 590 600
IFAMNKMDKP NVNPDKLKAE CAELGYNPVD WGGEHEFIPV SAKTGDGIDN
610 620 630 640 650
LLETILIQAD IMELKAIEEG SARAVVLEGS VEKGRGAVAT VIVQSGTLSV
660 670 680 690 700
GDSFFAETAF GKVRTMTDDQ GKSIQNLKPS MVALITGLSE VPPAGSVLIG
710 720 730 740 750
VENDSIARLQ AQKRATYLHQ KALSKSTKVS FDELSEMVAN KELKNIPVVI
760 770 780 790 800
KADTQGSLEA IKNSLLELNN EEVAIQVIHS GVGGITENDL SLVSNSEHAV
810 820 830 840 850
ILGFNIRPTG NVKNKAKEYN VSIKTYTVIY ALIEEMRSLL LGLMSPIIEE
860 870 880 890 900
EHTGQAEVRE TFNIPKVGTI AGCVVSDGVI ARGIKARLIR DGVVIHTGEI
910 920 930 940
LSLKRFKDDV KEVSKGYECG IMLDNYNEIK VGDVFETYKE IHKKRTL
Length:947
Mass (Da):105,682
Last modified:December 16, 2008 - v1
Checksum:iFE2C4C36621F1DC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ07553.1.
RefSeqiWP_001293382.1. NC_011498.1.
YP_002301033.1. NC_011498.1.

Genome annotation databases

EnsemblBacteriaiACJ07553; ACJ07553; HPP12_0396.
GeneIDi7010770.
KEGGihpp:HPP12_0396.
PATRICi20608754. VBIHelPyl2824_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA. Translation: ACJ07553.1.
RefSeqiWP_001293382.1. NC_011498.1.
YP_002301033.1. NC_011498.1.

3D structure databases

ProteinModelPortaliB6JKX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi570508.HPP12_0396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ07553; ACJ07553; HPP12_0396.
GeneIDi7010770.
KEGGihpp:HPP12_0396.
PATRICi20608754. VBIHelPyl2824_0418.

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiANQPAKN.
OrthoDBiEOG67HJSV.

Enzyme and pathway databases

BioCyciHPYL570508:GJ8D-409-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Helicobacter pylori strain P12."
    Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P12.

Entry informationi

Entry nameiIF2_HELP2
AccessioniPrimary (citable) accession number: B6JKX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: March 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.