B6JJ40 (KHSE_OLICO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	OCAR_7330, OCA5_c07880

Organism

Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5) [Complete proteome] [HAMAP]

Taxonomic identifier

504832 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Oligotropha

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_1000115436

Sequences

	Sequence		Length	Mass (Da)
	B6JJ40 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: 3C57E882308E5F34	FASTA	326	35,465
	10 20 30 40 50 60 MAVYTDVAAD ELADFLSGYD LGDLLSYKGI AEGVENSNFL LHTTRGHFFL TLYEKRVAKA 70 80 90 100 110 120 DLPFFLNLMG HLAARGITCP QPVANRGGET LGTLAGRPAA IIDFLEGVWP RKVSVPHCAA 130 140 150 160 170 180 IGEALAKLHL AGADFKMTRA NALSVAGWRP LFEAAVARAD TVQAGLRDFL ATELAHLEAN 190 200 210 220 230 240 WPQALPRGII HADLFPDNAL FVGDTLSGLI DFYFACNDLL AYDVAICLNA WCFEADHSFN 250 260 270 280 290 300 VTKASTFLNA YGKVRPLSEP EQAALPLLAR GAALRFLLTR LVDWLNVPPG ALVKPKDPLE 310 320 YVRKLRFHQG VRTIAGYGLA RSESVT

References

[1]	"Genome sequence of the chemolithoautotrophic bacterium Oligotropha carboxidovorans OM5T." Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L. J. Bacteriol. 190:5531-5532(2008) [PubMed: 18539730] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49405 / DSM 1227 / OM5.
[2]	"Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5." Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O. J. Bacteriol. 193:5043-5043(2011) [PubMed: 21742883] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49405 / DSM 1227 / OM5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001196 Genomic DNA. Translation: ACI94434.1. CP002826 Genomic DNA. Translation: AEI05510.1.
RefSeq	YP_002290299.1. NC_011386.1. YP_004631751.1. NC_015684.1.
3D structure databases
ProteinModelPortal	B6JJ40.
SMR	B6JJ40. Positions 5-320.
ModBase	Search...
Protein-protein interaction databases
STRING	B6JJ40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10845920. 6992807.
GenomeReviews	Gene locus OCAR_7330 in contig CP001196_GR.
KEGG	oca:OCAR_7330.
PATRIC	22808451. VBIOliCar134280_3170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_OLICO

Accession

Primary (citable) accession number: B6JJ40
Secondary accession number(s): F8BZ19

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	December 16, 2008
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program