Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOCAR504832:G1GTX-3145-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:OCAR_7301, OCA5_c08150
OrganismiOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Taxonomic identifieri504832 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
Proteomesi
  • UP000007730 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000903451 – 205Holliday junction ATP-dependent DNA helicase RuvAAdd BLAST205

Proteomic databases

PRIDEiB6JIZ6

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Protein-protein interaction databases

STRINGi504832.OCA5_c08150

Structurei

3D structure databases

ProteinModelPortaliB6JIZ6
SMRiB6JIZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KA4 Bacteria
COG0632 LUCA
HOGENOMiHOG000057115
KOiK03550
OMAiDCHGVGY
OrthoDBiPOG091H02EF

Family and domain databases

CDDicd14332 UBA_RuvA_C, 1 hit
HAMAPiMF_00031 DNA_helic_RuvA, 1 hit
InterProiView protein in InterPro
IPR013849 DNA_helicase_Holl-junc_RuvA_I
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR012340 NA-bd_OB-fold
IPR000085 RuvA
IPR010994 RuvA_2-like
IPR011114 RuvA_C
IPR036267 RuvA_C_sf
PANTHERiPTHR33796 PTHR33796, 1 hit
PfamiView protein in Pfam
PF07499 RuvA_C, 1 hit
PF01330 RuvA_N, 1 hit
SMARTiView protein in SMART
SM00278 HhH1, 2 hits
SUPFAMiSSF46929 SSF46929, 1 hit
SSF47781 SSF47781, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00084 ruvA, 1 hit

Sequencei

Sequence statusi: Complete.

B6JIZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGKLKGVID SYGEDYVILD VQGVGYLVHC ATRTLQALPS SGEAAVLSIE
60 70 80 90 100
TYVREDQIKL FGFRSDIERE WFRLLQTVQG VGAKVALAVL STLPPSDLAN
110 120 130 140 150
AIALRDKAAV ARTPGVGPKV AERIVTELKD KAPAFANVDP AVVHLAGAVD
160 170 180 190 200
DDRAPRPVKD AISALVNLGY GQPQAAAAIA SVARDAGEGA ETAQLIRLGL

KELAK
Length:205
Mass (Da):21,595
Last modified:December 16, 2008 - v1
Checksum:i99C5FE1F22EE104C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001196 Genomic DNA Translation: ACI94405.1
CP002826 Genomic DNA Translation: AEI05537.1
RefSeqiWP_012564431.1, NC_015684.1

Genome annotation databases

EnsemblBacteriaiACI94405; ACI94405; OCAR_7301
AEI05537; AEI05537; OCA5_c08150
KEGGioca:OCAR_7301
ocg:OCA5_c08150
PATRICifig|504832.7.peg.861

Similar proteinsi

Entry informationi

Entry nameiRUVA_OLICO
AccessioniPrimary (citable) accession number: B6JIZ6
Secondary accession number(s): F8BZ46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health