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B6JG66 (B6JG66_OLICO) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 HAMAP MF_00191
EC=1.17.1.2 HAMAP MF_00191
Gene names
Name:ispH EMBL ACI93778.1
Synonyms:ispH2 HAMAP MF_00191 EMBL AEI06117.1
Ordered Locus Names:OCA5_c14010 EMBL AEI06117.1, OCAR_6667
OrganismOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5) [Complete proteome] [HAMAP]
Taxonomic identifier504832 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Oligotropha

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. SAAS SAAS003451 HAMAP MF_00191

Catalytic activity

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. SAAS SAAS003451 HAMAP MF_00191

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. SAAS SAAS003451 HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. SAAS SAAS003451 HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. SAAS SAAS003451 HAMAP MF_00191

Sequence similarities

Belongs to the IspH family. HAMAP MF_00191

Sequences

Sequence LengthMass (Da)Tools
B6JG66 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: 98EDF6E8AF382BAA

FASTA32234,661
        10         20         30         40         50         60 
MLNRAPIQVL LAQPRGFCAG VVRAIEIVER ALEQYGPPVY VRHEIVHNKY VVESLKAKGA 

        70         80         90        100        110        120 
VFVEDVHEVP DNAITVFSAH GVAKSVEQEA ASRNLPVLDA TCPLVSKVHN QGKRYVGKGR 

       130        140        150        160        170        180 
RLVLIGHDGH PEVVGTMGQV PGPVTLVQSV EDVARLDIPT DAPVAYITQT TLSVDDTKDI 

       190        200        210        220        230        240 
IAALAARFPD LEGPDTRDIC YATQNRQSSV RDLSKHADLI LVVGATNSSN SNRLREIGAE 

       250        260        270        280        290        300 
VGVPSYLIAD GSQLNPDWLH GVKTVGITAG ASAPEVLVDD VIDALRRIVP VTVDVLPGRE 

       310        320 
ENIEFKLPPE LTSVRVRAGA EL

« Hide

References

[1]"Genome sequence of the chemolithoautotrophic bacterium Oligotropha carboxidovorans OM5T."
Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L.
J. Bacteriol. 190:5531-5532(2008) [PubMed: 18539730] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49405 / DSM 1227 / OM5 [Mississippi].
[2]"Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
J. Bacteriol. 193:5043-5043(2011) [PubMed: 21742883] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49405 / DSM 1227 / OM5 and OM5 EMBL AEI06117.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001196 Genomic DNA. Translation: ACI93778.1.
CP002826 Genomic DNA. Translation: AEI06117.1.
RefSeqYP_002289643.1. NC_011386.1.
YP_004632358.1. NC_015684.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB6JG66.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID10846533.
6990691.
GenomeReviewsGene locus OCAR_6667 in contig CP001196_GR.
KEGGoca:OCAR_6667.
PATRIC22807153. VBIOliCar134280_2526.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG335228.
OMAHNQGKRY.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB6JG66_OLICO
AccessionPrimary (citable) accession number: B6JG66
Entry history
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info