ID B6JFK1_AFIC5 Unreviewed; 889 AA. AC B6JFK1; DT 16-DEC-2008, integrated into UniProtKB/TrEMBL. DT 16-DEC-2008, sequence version 1. DT 27-MAR-2024, entry version 89. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=OCA5_c11710 {ECO:0000313|EMBL:AEI05889.1}; OS Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) OS (Oligotropha carboxidovorans). OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales; OC Nitrobacteraceae; Afipia. OX NCBI_TaxID=504832 {ECO:0000313|EMBL:AEI05889.1, ECO:0000313|Proteomes:UP000007730}; RN [1] {ECO:0000313|EMBL:AEI05889.1, ECO:0000313|Proteomes:UP000007730} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 49405 / DSM 1227 / KCTC 32145 / OM5 RC {ECO:0000313|Proteomes:UP000007730}; RX PubMed=21742883; DOI=10.1128/JB.05619-11; RA Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., RA Meyer O.; RT "Complete genome sequences of the chemolithoautotrophic Oligotropha RT carboxidovorans strains OM4 and OM5."; RL J. Bacteriol. 193:5043-5043(2011). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP002826; AEI05889.1; -; Genomic_DNA. DR RefSeq; WP_012564047.1; NC_015684.1. DR AlphaFoldDB; B6JFK1; -. DR STRING; 504832.OCA5_c11710; -. DR KEGG; ocg:OCA5_c11710; -. DR PATRIC; fig|504832.7.peg.1245; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_0_1_5; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000007730; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AEI05889.1}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000007730}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 344..437 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 187..215 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 889 AA; 98231 MW; 7ACC5D10DBF384F7 CRC64; MTRKKLSVYQ TKRDFTKTAE PSGAAKVTRG KLPRFVIQKH DATRLHYDLR LEIDGIFKSW AVTRGPSLDP KDKRLAVEVE DHPLDYGDFE GTIPKGQYGG GTVMLWDRGF WHSDDPAGGL KKGDLKFTLE GKKLHGEWVL VRMRHDRTGG KRTNWLLIKH RDEAAREGED ILDQDRSVAS GRTMEQIAQG KGRGPTPFMT AKGNAKPSRS KADRVWQSNQ GTAAALRAKS VAKTKTLAKP VQAAVRKVDH LPEFIAPQLC KSVARPSDGA DWIHEIKFDG YRMQLHIQGG KVHLRTRKGL DWTDKFPAIA KAAAKLPECI IDGEIVALDH EGHPSFASLQ AALSDGDTDE LIFFAFDLLF DKDSDLRRLP LTERKARLEQ LLDRQSKTSV IRYVAHFDTG GDAVLKSACR LALEGIISKR RDALYHSGRT ESWTKAKCRA GHEVVIGGWK TTAGKFRSLM VGVPHEDHLA YVGIVGTGYG QAVVKRIMPE LKKVASTTNP FGGKNAPRKT TGVHWVKPEL VAEIEFAGWT GDNMVRQAAF KGLRKDKSAD EVQVDEPVVT PIAEPAPRKT NTKANTKTRA KAATRTSSSG NAVVMGLTIS KPDKPLWPDD GKGEPVTKLD LARYMETMGE YLLPHIEGRP CSIIRAPDGI EGEKFFQRHA TAGMSNLIDQ VRVSGDRKPY IQIDRIEGLV AAAQIGGVEF HPWNCAPNEP DVPGRLVFDL DPAPGVNFTD VITAARDLHD RLSSLGLESF CKTTGGKGLH VVTPLKDAKK DRIDWKAAKA FAQAVCQAMA ADAPERYLIN MSKKKREGKI FLDYLRNDRM STAVAPFSPR GRDFAPVAWP ITWAQARTGL DPLKFTLRTV PALVKTSKAW AGYDRAARSL KDAIRKMGG //