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B6JCQ3

- DUT_OLICO

UniProt

B6JCQ3 - DUT_OLICO

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851SubstrateUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciOCAR504832:GJPZ-46-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:OCAR_4488, OCA5_c00460
    OrganismiOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5)
    Taxonomic identifieri504832 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
    ProteomesiUP000001678: Chromosome, UP000007730: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 152152Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000094974Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi504832.OCAR_4488.

    Structurei

    3D structure databases

    ProteinModelPortaliB6JCQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni72 – 743Substrate bindingUniRule annotation
    Regioni89 – 913Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    HOGENOMiHOG000028966.
    KOiK01520.
    OMAiEPMERIA.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6JCQ3-1 [UniParc]FASTAAdd to Basket

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    MTEPLRIAVT QLPHGQGLPL PAYQTEHAAG LDLLAAVPED KPLAIAPGER    50
    ALVPTGLAIA LPAGYEAQVR PRSGLAVKHG VTVLNAPGTI DADYRGEIGV 100
    PLINHGRETF IIRRGERIAQ MVVAPVVQIA FEPVAELPMS ARGAGGFGST 150
    GR 152
    Length:152
    Mass (Da):15,849
    Last modified:December 16, 2008 - v1
    Checksum:i1343AF206F224CD5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001196 Genomic DNA. Translation: ACI91633.1.
    CP002826 Genomic DNA. Translation: AEI04780.1.
    RefSeqiWP_012561664.1. NC_015684.1.
    YP_002287498.1. NC_011386.1.
    YP_004631021.1. NC_015684.1.

    Genome annotation databases

    EnsemblBacteriaiACI91633; ACI91633; OCAR_4488.
    AEI04780; AEI04780; OCA5_c00460.
    GeneIDi10845178.
    6993241.
    KEGGioca:OCAR_4488.
    ocg:OCA5_c00460.
    PATRICi22802957. VBIOliCar134280_0464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001196 Genomic DNA. Translation: ACI91633.1 .
    CP002826 Genomic DNA. Translation: AEI04780.1 .
    RefSeqi WP_012561664.1. NC_015684.1.
    YP_002287498.1. NC_011386.1.
    YP_004631021.1. NC_015684.1.

    3D structure databases

    ProteinModelPortali B6JCQ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 504832.OCAR_4488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACI91633 ; ACI91633 ; OCAR_4488 .
    AEI04780 ; AEI04780 ; OCA5_c00460 .
    GeneIDi 10845178.
    6993241.
    KEGGi oca:OCAR_4488.
    ocg:OCA5_c00460.
    PATRICi 22802957. VBIOliCar134280_0464.

    Phylogenomic databases

    eggNOGi COG0756.
    HOGENOMi HOG000028966.
    KOi K01520.
    OMAi EPMERIA.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci OCAR504832:GJPZ-46-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the chemolithoautotrophic bacterium Oligotropha carboxidovorans OM5T."
      Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L.
      J. Bacteriol. 190:5531-5532(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49405 / DSM 1227 / OM5.
    2. "Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
      Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
      J. Bacteriol. 193:5043-5043(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49405 / DSM 1227 / OM5.

    Entry informationi

    Entry nameiDUT_OLICO
    AccessioniPrimary (citable) accession number: B6JCQ3
    Secondary accession number(s): F8C081
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3