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B6JCL3 (UPPP_OLICO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:OCAR_4447, OCA5_c00850
OrganismOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5) [Complete proteome] [HAMAP]
Taxonomic identifier504832 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197385

Regions

Transmembrane43 – 6321Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B6JCL3 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: D103BF4E724B0DDE

FASTA26829,408
        10         20         30         40         50         60 
MLFDLFKALV LGIVEGVTEF LPVSSTGHIL LAERIFDLDQ DNFWKTFAVL IQLGAILAIL 

        70         80         90        100        110        120 
AIYFQRLWRV ATHMFTDPAA RRFVIGVLVA FLPAVILGLI FGTFIKEVLF NPWVVCFSLI 

       130        140        150        160        170        180 
AGGAVLLWVD QQDVNPRHHD AMAFPLPMYL GIGIAQCAAM VPGVSRSGAS IVAAMLFGAD 

       190        200        210        220        230        240 
KRAAAEFSFF LAIPTMLGAF VYDVYKSRGD MTMDHAFIII VGFVVSFITA IVVVKTFLDF 

       250        260 
VTKNGFTFFA WWRVIVGTLG LIALALGA 

« Hide

References

[1]"Genome sequence of the chemolithoautotrophic bacterium Oligotropha carboxidovorans OM5T."
Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L.
J. Bacteriol. 190:5531-5532(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49405 / DSM 1227 / OM5.
[2]"Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
J. Bacteriol. 193:5043-5043(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49405 / DSM 1227 / OM5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001196 Genomic DNA. Translation: ACI91593.1.
CP002826 Genomic DNA. Translation: AEI04817.1.
RefSeqYP_002287458.1. NC_011386.1.
YP_004631058.1. NC_015684.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING504832.OCAR_4447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI91593; ACI91593; OCAR_4447.
AEI04817; AEI04817; OCA5_c00850.
GeneID10845217.
6993201.
KEGGoca:OCAR_4447.
ocg:OCA5_c00850.
PATRIC22802873. VBIOliCar134280_0424.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycOCAR504832:GJPZ-85-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_OLICO
AccessionPrimary (citable) accession number: B6JCL3
Secondary accession number(s): F8C0B8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families