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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi252Magnesium or manganese 1UniRule annotation1
Metal bindingi269Magnesium or manganese 1UniRule annotation1
Metal bindingi269Magnesium or manganese 2UniRule annotation1
Metal bindingi271Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi130 – 184ATPUniRule annotationAdd BLAST55

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOCAR504832:G1GTX-1198-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:OCAR_5247, OCA5_c27220
OrganismiOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Taxonomic identifieri504832 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
Proteomesi
  • UP000007730 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000911991 – 308D-alanine--D-alanine ligaseAdd BLAST308

Proteomic databases

PRIDEiB6JB38

Interactioni

Protein-protein interaction databases

STRINGi504832.OCA5_c27220

Structurei

3D structure databases

ProteinModelPortaliB6JB38
SMRiB6JB38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 302ATP-graspUniRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000011592
KOiK01921
OMAiIPYVGCD
OrthoDBiPOG091H00GT

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B6JB38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALQHVAVL MGGWSSEREV SLRSGAACAA ALERKGYRVT RIDVQRDIAT
60 70 80 90 100
VLQNLKPDVA LVMLHGKPGE DGTIQGVLET LGIPYSHSGV LSSSLAMRKD
110 120 130 140 150
LAKTVMATAG VPVAEGLTLT RAEIAKAHVM APPYVIKPVA DGSSVGVFIV
160 170 180 190 200
TEDQAHPPQE LFRDDWPHGE ELLVEKYIAG RELTCAVIKG EASDVIEIVP
210 220 230 240 250
LLKFYDYEAK YSKGASKHVL PAPVLPFVYQ EVRRLTLAAH GALGCRGVSR
260 270 280 290 300
ADFRYDDRIE GTGGLVCLEV NTQPGMTETS LVPELAGYAG VAFDELVQWM

VEDASLDR
Length:308
Mass (Da):33,238
Last modified:December 16, 2008 - v1
Checksum:iFD911E66442DB8CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001196 Genomic DNA Translation: ACI92379.1
CP002826 Genomic DNA Translation: AEI07416.1
RefSeqiWP_012562408.1, NC_015684.1

Genome annotation databases

EnsemblBacteriaiACI92379; ACI92379; OCAR_5247
AEI07416; AEI07416; OCA5_c27220
KEGGioca:OCAR_5247
ocg:OCA5_c27220
PATRICifig|504832.7.peg.2878

Similar proteinsi

Entry informationi

Entry nameiDDL_OLICO
AccessioniPrimary (citable) accession number: B6JB38
Secondary accession number(s): F8BV61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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