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B6JAI4

- SYL_OLICO

UniProt

B6JAI4 - SYL_OLICO

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Protein
Leucine--tRNA ligase
Gene
leuS, OCAR_4363, OCA5_c01660
Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOCAR504832:GJPZ-166-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:OCAR_4363, OCA5_c01660
OrganismiOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5)
Taxonomic identifieri504832 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
ProteomesiUP000001678: Chromosome, UP000007730: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Leucine--tRNA ligaseUniRule annotation
PRO_1000091340Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi504832.OCAR_4363.

Structurei

3D structure databases

ProteinModelPortaliB6JAI4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi636 – 6405"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6JAI4-1 [UniParc]FASTAAdd to Basket

« Hide

MSTERYNARE VEPRWQQIWD EKGVFASRND DSRPKYYVLE MFPYPSGRIH    50
MGHVRNYTMG DVVARYRRAK GHNVLHPMGW DAFGMPAENA AMQNKTHPAK 100
WTYANIAAMK KQLKSMGLSL DWAREIATCD PSYYKHQQRM FLDFLKAGLV 150
ERKQSKVNWD PVDQTVLANE QVIDGRGWRS GALVEQRELT QWFFKISDYS 200
EELLTALDTL DRWPEKVRLM QKNWIGRSEG LLVRFALDAA TAPAGESEVE 250
VFTTRPDTLF GAKFVALSPD HPLAAEVAKA NPKLEAFIAE CHRHGTAQAE 300
IDTAEKLGFD TGLRARHPFD PDWLLPVYVA NFVLMDYGTG AIFGCPAHDQ 350
RDLDFVNKYG LGNTPVVCPE GQDPKSFVIT DTAYDGDGRM INSRFLDGMT 400
IADAKEDVAK RLETATLPRA NGGGNAPVAK RQVNYRLRDW GISRQRYWGC 450
PIPIIHCESC GIVPVPVKDL PVKLPDDIEF DRPGNPLDRH PTWKHVACPQ 500
CGGKARRETD TMDTFVDSSW YFARFTDPWN ENAPTTRKVV DAMMPVDQYI 550
GGIEHAILHL LYSRFFTRAM KATGHVGFDE PFAGLFTQGM VVHETYKNAD 600
GSWAAPSEIK IEGTGDARHA TLIDTGAPVE IGSIEKMSKS KRNTIDPDDI 650
IGTYGADTAR WFMLSDSPPD RDVIWSEEGV QGANRFVQRV WRLVNLAAPH 700
LPKDSAAAGT SADTKPLRST AHRTLADVSQ AIERLRFNTA IAKLYAFVGP 750
LNEAIDDPRL KADPAWAASV REALDMLVRM IAPMMPHLAE QCWEALGGQG 800
LVSEAAWPEV DPVLLVEDTI TLPVQINGKK RADVTVGRNA PNPEIEAAVL 850
ALDAVKTALA GATPRKIIVV PQRIVNVVV 879
Length:879
Mass (Da):98,025
Last modified:December 16, 2008 - v1
Checksum:i9C29A2C1EF90A0A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001196 Genomic DNA. Translation: ACI91509.1.
CP002826 Genomic DNA. Translation: AEI04898.1.
RefSeqiYP_002287374.1. NC_011386.1.
YP_004631139.1. NC_015684.1.

Genome annotation databases

EnsemblBacteriaiACI91509; ACI91509; OCAR_4363.
AEI04898; AEI04898; OCA5_c01660.
GeneIDi10845298.
6993117.
KEGGioca:OCAR_4363.
ocg:OCA5_c01660.
PATRICi22802705. VBIOliCar134280_0340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001196 Genomic DNA. Translation: ACI91509.1 .
CP002826 Genomic DNA. Translation: AEI04898.1 .
RefSeqi YP_002287374.1. NC_011386.1.
YP_004631139.1. NC_015684.1.

3D structure databases

ProteinModelPortali B6JAI4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 504832.OCAR_4363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI91509 ; ACI91509 ; OCAR_4363 .
AEI04898 ; AEI04898 ; OCA5_c01660 .
GeneIDi 10845298.
6993117.
KEGGi oca:OCAR_4363.
ocg:OCA5_c01660.
PATRICi 22802705. VBIOliCar134280_0340.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci OCAR504832:GJPZ-166-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chemolithoautotrophic bacterium Oligotropha carboxidovorans OM5T."
    Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L.
    J. Bacteriol. 190:5531-5532(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49405 / DSM 1227 / OM5.
  2. "Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5."
    Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O.
    J. Bacteriol. 193:5043-5043(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49405 / DSM 1227 / OM5.

Entry informationi

Entry nameiSYL_OLICO
AccessioniPrimary (citable) accession number: B6JAI4
Secondary accession number(s): F8BS31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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