B6JA10 (B6JA10_OLICO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Hydroxyacylglutathione hydrolase HAMAP MF_01374
EC=3.1.2.6 HAMAP MF_01374

Alternative name(s):
Glyoxalase II HAMAP MF_01374

Gene names

Name:	gloB HAMAP MF_01374 EMBL ACI91253.1
Ordered Locus Names:	OCA5_c04080 EMBL AEI05133.1, OCAR_4102

Organism

Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / OM5) [Complete proteome] [HAMAP]

Taxonomic identifier

504832 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Oligotropha

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. SAAS SAAS017782 HAMAP MF_01374
Catalytic activity	S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. SAAS SAAS017782 HAMAP MF_01374
Cofactor	Binds 2 zinc ions per subunit By similarity. SAAS SAAS017782 HAMAP MF_01374
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374
Subunit structure	Monomer By similarity. SAAS SAAS017782 HAMAP MF_01374
Sequence similarities	Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. HAMAP MF_01374

Ontologies

Keywords
Ligand	Metal-binding SAAS SAAS017782 HAMAP MF_01374 Zinc SAAS SAAS017782 HAMAP MF_01374
Molecular function	Hydrolase SAAS SAAS017782 HAMAP MF_01374 EMBL ACI91253.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B6JA10 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: DF6AEA136C74336C	FASTA	255	28,141
	10 20 30 40 50 60 MAAEIRVFPC LSDNIGYLIH DPVTKATAAI DAPDAKPIIA ALEREGWRLT DLLITHHHAD 70 80 90 100 110 120 HTDGIAELKA KYKCRVVGPY EKGVRIDGLD VHVKEGDTVK VGNLVARVFE TPGHTLDHIS 130 140 150 160 170 180 YMFDDAHALF CADVIFSIGC GRVIEGTYPM MWESLLKLRA LPNDTRVYCG HEYTASNVKF 190 200 210 220 230 240 ALGIEPNNPA LKKRAEEVTK LRAEGKLTIP SLMRDEKEAN VFLRADVPAV AAALGMNGKT 250 PAEVFGEIRE RKNRA

References

[1]	"Genome sequence of the chemolithoautotrophic bacterium Oligotropha carboxidovorans OM5T." Paul D., Bridges S., Burgess S.C., Dandass Y., Lawrence M.L. J. Bacteriol. 190:5531-5532(2008) [PubMed: 18539730] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49405 / DSM 1227 / OM5 [Mississippi].
[2]	"Complete genome sequences of the chemolithoautotrophic Oligotropha carboxidovorans strains OM4 and OM5." Volland S., Rachinger M., Strittmatter A., Daniel R., Gottschalk G., Meyer O. J. Bacteriol. 193:5043-5043(2011) [PubMed: 21742883] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49405 / DSM 1227 / OM5 and OM5 EMBL AEI05133.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001196 Genomic DNA. Translation: ACI91253.1. CP002826 Genomic DNA. Translation: AEI05133.1.
RefSeq	YP_002287118.1. NC_011386.1. YP_004631374.1. NC_015684.1.
3D structure databases
ProteinModelPortal	B6JA10.
ModBase	Search...
Protein-protein interaction databases
STRING	B6JA10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10845540. 6991565.
GenomeReviews	Gene locus OCAR_4102 in contig CP001196_GR.
KEGG	oca:OCAR_4102.
PATRIC	22802211. VBIOliCar134280_0098.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG753931.
OMA	IGCGRVF.
ProtClustDB	CLSK818037.
Family and domain databases
HAMAP	MF_01374. Glyoxalase_2. [Tree]
InterPro	IPR001279. Beta-lactamas-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view]
KO	K01069.
PANTHER	PTHR11935:SF7. PTHR11935:SF7. 1 hit.
Pfam	PF00753. Lactamase_B. 1 hit. [Graphical view]
SMART	SM00849. Lactamase_B. 1 hit. [Graphical view]
TIGRFAMs	TIGR03413. GSH_gloB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B6JA10_OLICO

Accession

Primary (citable) accession number: B6JA10

Entry history

Integrated into UniProtKB/TrEMBL:	December 16, 2008
Last sequence update:	December 16, 2008
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)