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Protein

Pantothenate synthetase

Gene

panC

Organism
Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36Proton donorUniRule annotation1
Binding sitei60Beta-alanineUniRule annotation1
Binding sitei60PantoateUniRule annotation1
Binding sitei151PantoateUniRule annotation1
Binding sitei174ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 36ATPUniRule annotation8
Nucleotide bindingi145 – 148ATPUniRule annotation4
Nucleotide bindingi182 – 185ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:CbuK_1645
OrganismiCoxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Taxonomic identifieri434924 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000970531 – 257Pantothenate synthetaseAdd BLAST257

Proteomic databases

PRIDEiB6J9H9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB6J9H9
SMRiB6J9H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000175517
KOiK01918
OMAiQITKPDN

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

B6J9H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVIEALSD WQSIRKTIND LSVGFVPTMG NLHAGHLSLL ERSKCENTIT
60 70 80 90 100
VLSLFINPTQ FNDKNDFKNY PRTLAQDIAM AEENGIDYVL APTDDALYPD
110 120 130 140 150
QYAYKITNST INNQEAEFRP RHFDGVLTVV MKLLLLVKPT RAYFGEKDYQ
160 170 180 190 200
QLQLVKGLAE AFFLDTEIIG CKIVRNEFGL PLSSRNRRLT EDQYQLAQRF
210 220 230 240 250
SEIFHSDLSC DEIKNALIQE GIIVDYIEDY NERRFAAVHV GDIRLIDNIP

FAKDKKC
Length:257
Mass (Da):29,479
Last modified:December 16, 2008 - v1
Checksum:i2A8DD0535687A595
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001020 Genomic DNA Translation: ACJ20793.1
RefSeqiWP_005771941.1, NZ_CCXO01000003.1

Genome annotation databases

EnsemblBacteriaiACJ20793; ACJ20793; CbuK_1645
KEGGicbc:CbuK_1645

Similar proteinsi

Entry informationi

Entry nameiPANC_COXB1
AccessioniPrimary (citable) accession number: B6J9H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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