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B6J887

- PYRF_COXB1

UniProt

B6J887 - PYRF_COXB1

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, CbuK_1305
Organism
Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Substrate By similarity
Binding sitei35 – 351Substrate By similarity
Active sitei64 – 641Proton donor By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei193 – 1931Substrate By similarity
Binding sitei213 – 2131Substrate; via amide nitrogen By similarity
Binding sitei214 – 2141Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCBUR434924:GHWU-1302-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:CbuK_1305
OrganismiCoxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Taxonomic identifieri434924 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002504: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000138517Add
BLAST

Proteomic databases

PRIDEiB6J887.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi434924.CbuK_1305.

Structurei

3D structure databases

ProteinModelPortaliB6J887.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 7110Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6J887-1 [UniParc]FASTAAdd to Basket

« Hide

MEKPDPKVIV AIDAGTVEQA RAQINPLTPE LCHLKIGSIL FTRYGPAFVE    50
ELMQKGYRIF LDLKFYDIPQ TVAGACRAVA ELGVWMMNIH ISGGRTMMET 100
VVNALQSITL KEKPLLIGVT ILTSLDGSDL KTLGIQEKVP DIVCRMATLA 150
KSAGLDGVVC SAQEAALLRK QFDRNFLLVT PGIRLETDEK GDQKRVMTPR 200
AAIQAGSDYL VIGRPITQST DPLKALEAID KDIKTR 236
Length:236
Mass (Da):25,849
Last modified:December 16, 2008 - v1
Checksum:i6299A5996F538ECA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001020 Genomic DNA. Translation: ACJ20486.1.
RefSeqiYP_002305631.1. NC_011528.1.

Genome annotation databases

EnsemblBacteriaiACJ20486; ACJ20486; CbuK_1305.
GeneIDi7015818.
KEGGicbc:CbuK_1305.
PATRICi17918070. VBICoxBur77120_1327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001020 Genomic DNA. Translation: ACJ20486.1 .
RefSeqi YP_002305631.1. NC_011528.1.

3D structure databases

ProteinModelPortali B6J887.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434924.CbuK_1305.

Proteomic databases

PRIDEi B6J887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ20486 ; ACJ20486 ; CbuK_1305 .
GeneIDi 7015818.
KEGGi cbc:CbuK_1305.
PATRICi 17918070. VBICoxBur77120_1327.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CBUR434924:GHWU-1302-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CbuK_Q154.

Entry informationi

Entry nameiPYRF_COXB1
AccessioniPrimary (citable) accession number: B6J887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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