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B6J863

- SYL_COXB1

UniProt

B6J863 - SYL_COXB1

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Protein
Leucine--tRNA ligase
Gene
leuS, CbuK_1279
Organism
Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR434924:GHWU-1276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CbuK_1279
OrganismiCoxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Taxonomic identifieri434924 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002504: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Leucine--tRNA ligaseUniRule annotation
PRO_1000091309Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi434924.CbuK_1279.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6J863-1 [UniParc]FASTAAdd to Basket

« Hide

MNESYQPTLI EQLAQEYWEE NETFEVKEDL SREKFYCLSM LPYPSGDLHM    50
GHVRNYTIGD VIARYQIHKG RNVLQPMGWD AFGLPAENAA IQRELPPAEW 100
TRKNIKKMRK QLKQLGFAYD WSREITTCDS TYYRWEQWLF LQLYKKGLAY 150
KKNAIVNWDP VDQTVLANEQ IVDGRGWRSG AVVERREISQ WFLKITDYSE 200
ELLKDLDELK EWPEQVITMQ RNWIGQSQGV IINFNLEKGP DKLQVYTTRP 250
DTLMGVTYLA IAPEHPLAKE RAKKSKKIAA FLKKCKQTRV AEADIATQEK 300
EGIDSGLFAV HPLSKEKLPI WIANFVLMEY ASGVVMAVPA HDERDHEFAL 350
KYDLPLKPVI EPADGHDWDY NQAAYTNPGK LINSGSFNDI DSKTAFNVIA 400
DYLKNNGAGS RQTHYRLRDW GISRQRYWGT PIPIIYCKTC GTVPVPENQL 450
PVLLPEDIIP TGHGSPLKET ASFYKTRCPV CNKPATRETD TMDTFVESSW 500
YYARYSCPDQ DKVMLDDRAK YWTPVDQYIG GIEHAVMHLL YARFMHKILR 550
DLGLLNSNEP FIRLLTQGMV LKDGAKMSKS KGNVVTPQSL IKKYGADTVR 600
LFIIFAAPPE QDLEWSDSGV EGAYRFLKKL WGFSYRIKDA LLAINQQKER 650
SNYQWEAPEH RQTRQQIHEC LQQANIDMER LQFNTVVSAV MKILNILIKL 700
TTDNDAEAHL IREGTGILLR LLSPITPHIS HHLWQSLGFG GDILDAPWPR 750
PDPKALQTTE LELIVQINGK LRGRIQVPTE ASKEIIESTA LNQENVQRHL 800
ADKKIKKVIV VPKKLINILV 820
Length:820
Mass (Da):94,243
Last modified:December 16, 2008 - v1
Checksum:i1D08D3EE02378FE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001020 Genomic DNA. Translation: ACJ20462.1.
RefSeqiYP_002305607.1. NC_011528.1.

Genome annotation databases

EnsemblBacteriaiACJ20462; ACJ20462; CbuK_1279.
GeneIDi7015792.
KEGGicbc:CbuK_1279.
PATRICi17918014. VBICoxBur77120_1299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001020 Genomic DNA. Translation: ACJ20462.1 .
RefSeqi YP_002305607.1. NC_011528.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434924.CbuK_1279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ20462 ; ACJ20462 ; CbuK_1279 .
GeneIDi 7015792.
KEGGi cbc:CbuK_1279.
PATRICi 17918014. VBICoxBur77120_1299.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CBUR434924:GHWU-1276-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CbuK_Q154.

Entry informationi

Entry nameiSYL_COXB1
AccessioniPrimary (citable) accession number: B6J863
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi