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B6J6J3

- B6J6J3_COXB1

UniProt

B6J6J3 - B6J6J3_COXB1

Protein

Thymidine kinase

Gene

tdk

Organism
Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorUniRule annotation
    Metal bindingi146 – 1461ZincUniRule annotation
    Metal bindingi148 – 1481ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi88 – 914ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCBUR434924:GHWU-2107-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotationImported
    Ordered Locus Names:CbuK_2112Imported
    OrganismiCoxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))Imported
    Taxonomic identifieri434924 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002504: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi434924.CbuK_2112.

    Structurei

    3D structure databases

    ProteinModelPortaliB6J6J3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076391.
    KOiK00857.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B6J6J3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLHFYYSA MNAGKSTTLL QSSYNYNERG MDTLVFLPVV DDREGERKIA    50
    TRIGLSGKAI ALTKGTNLFK CISDKLAENP NIRCVLVDEA QFLTKSQVEA 100
    LALVTDELNL PVLAYGIRTD FQGEPFEGSV YLLAWADLLI EIKTICHCGR 150
    KATMNLRIDD EGNPIREGEQ IRLGGNDRYT ATCRKHFRLG QPTQTK 196
    Length:196
    Mass (Da):21,950
    Last modified:December 16, 2008 - v1
    Checksum:i0AF9CFEE6AA6FC15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001020 Genomic DNA. Translation: ACJ21203.1.
    RefSeqiWP_005769872.1. NC_011528.1.
    YP_002306348.1. NC_011528.1.

    Genome annotation databases

    EnsemblBacteriaiACJ21203; ACJ21203; CbuK_2112.
    GeneIDi7016625.
    KEGGicbc:CbuK_2112.
    PATRICi17919686. VBICoxBur77120_2118.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001020 Genomic DNA. Translation: ACJ21203.1 .
    RefSeqi WP_005769872.1. NC_011528.1.
    YP_002306348.1. NC_011528.1.

    3D structure databases

    ProteinModelPortali B6J6J3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 434924.CbuK_2112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ21203 ; ACJ21203 ; CbuK_2112 .
    GeneIDi 7016625.
    KEGGi cbc:CbuK_2112.
    PATRICi 17919686. VBICoxBur77120_2118.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076391.
    KOi K00857.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci CBUR434924:GHWU-2107-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
      Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
      Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CbuK_Q154Imported.

    Entry informationi

    Entry nameiB6J6J3_COXB1
    AccessioniPrimary (citable) accession number: B6J6J3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 16, 2008
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3