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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCBUR434924:GHWU-2032-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:CbuK_2037
OrganismiCoxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Taxonomic identifieri434924 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_1000099319Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB6J646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

B6J646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARAINSRE KADLKYPRNT YIIGDVQGCY RELQELLELI QFDSTKDRLG
60 70 80 90 100
FVGDLVNRGP NSLEVLRFLK SLSSPLIVLG NHDLYLLILG YGLMPEDSYE
110 120 130 140 150
HTLHAVLQAP DKLELLEWLR HCPLIRYEKS LSAVLVHAGL PPQWNIKESI
160 170 180 190 200
LHAEEISTAL KGPHYLAFLK NLFGNEPSQW KEDLEGQDRL RYICNAFTRM
210 220 230 240 250
RFCDAKGHLD LESEGKTNQA PSRFRPWFEW RNPQEDNVDI VFGHWAALNG
260 270 280 290
QSSAPHTHAL DTGCAWGYKL TGINLKTKER FSVPCQSALR M
Length:291
Mass (Da):33,302
Last modified:December 16, 2008 - v1
Checksum:i3A44DE9A327CC770
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001020 Genomic DNA. Translation: ACJ21137.1.
RefSeqiWP_005769711.1. NC_011528.1.

Genome annotation databases

EnsemblBacteriaiACJ21137; ACJ21137; CbuK_2037.
KEGGicbc:CbuK_2037.
PATRICi17919526. VBICoxBur77120_2038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001020 Genomic DNA. Translation: ACJ21137.1.
RefSeqiWP_005769711.1. NC_011528.1.

3D structure databases

ProteinModelPortaliB6J646.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ21137; ACJ21137; CbuK_2037.
KEGGicbc:CbuK_2037.
PATRICi17919526. VBICoxBur77120_2038.

Phylogenomic databases

HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.

Enzyme and pathway databases

BioCyciCBUR434924:GHWU-2032-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPAH_COXB1
AccessioniPrimary (citable) accession number: B6J646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.