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B6J602 (B6J602_COXB1) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
EC=3.6.1.19 HAMAP-Rule MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405
Gene names
Ordered Locus Names:CbuK_1988 EMBL ACJ21093.1
OrganismCoxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154)) [Complete proteome] [HAMAP] EMBL ACJ21093.1
Taxonomic identifier434924 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella ›

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP-Rule MF_01405 SAAS SAAS002637

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP-Rule MF_01405 SAAS SAAS002637

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405 SAAS SAAS002637

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP-Rule MF_01405 RuleBase RU003781

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP-Rule MF_01405
Region69 – 702Substrate binding By similarity HAMAP-Rule MF_01405

Sites

Metal binding401Magnesium or manganese By similarity HAMAP-Rule MF_01405
Metal binding691Magnesium or manganese By similarity HAMAP-Rule MF_01405
Binding site1571Substrate By similarity HAMAP-Rule MF_01405
Binding site1771Substrate By similarity HAMAP-Rule MF_01405
Binding site1831Substrate By similarity HAMAP-Rule MF_01405

Sequences

Sequence LengthMass (Da)Tools
B6J602 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: A35DF16EE7025113

FASTA20021,777
        10         20         30         40         50         60 
MLEIVLASQN SSKLAEMQEL LRDLEIKFIP QTEFSVPDIE ETGSTFVENA IIKARHAAKQ 

        70         80         90        100        110        120 
TGLPALADDS GLTIAALNSA PGVFSSRYAG KNATDAERIQ KVLEALEAAD DSDRSASFHC 

       130        140        150        160        170        180 
VIALMENEND PAPLICHGVW EGEIAREPRG KNGFGYDPIF YVPSHQRTAA ELDPQEKNAI 

       190        200 
SHRGQALEQL STVLTEAFLV

« Hide

References

[1]"Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J.III., Porcella S.F., Samuel J.E., Heinzen R.A.
Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CbuK_Q154 EMBL ACJ21093.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001020 Genomic DNA. Translation: ACJ21093.1.
RefSeqYP_002306238.1. NC_011528.1.

3D structure databases

ProteinModelPortalB6J602.
SMRB6J602. Positions 1-195.
ModBaseSearch...

Protein-protein interaction databases

STRING434924.CbuK_1988.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ21093; ACJ21093; CbuK_1988.
GeneID7016501.
KEGGcbc:CbuK_1988.
PATRIC17919423. VBICoxBur77120_1988.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHOG000293319.
KOK02428.
ProtClustDBPRK00120.

Enzyme and pathway databases

BioCycCBUR434924:GHWU-1983-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB6J602_COXB1
AccessionPrimary (citable) accession number: B6J602
Entry history
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: May 29, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info