Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B6J4T8

- GCSPB_COXB1

UniProt

B6J4T8 - GCSPB_COXB1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Coxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCBUR434924:GHWU-294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:CbuK_0295
OrganismiCoxiella burnetii (strain CbuK_Q154) (Coxiella burnetii (strain Q154))
Taxonomic identifieri434924 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002504: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132498Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi434924.CbuK_0295.

Structurei

3D structure databases

ProteinModelPortaliB6J4T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B6J4T8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIFEKSRKN RRTLAHAIAD KMDANDIPAN LLRHDAPRLP ELSELEVVRH
60 70 80 90 100
FTRLSTQNFS IDTHFYPLGS CTMKYNPRAA NRLASLPGYL KRHPLSPAPQ
110 120 130 140 150
SQAFLQCLYE LQTMLTEITG MEKISLTSMA GAQGEFAGVA MIKAYHESRG
160 170 180 190 200
DYDRTEMIVP DAAHGTNPAS AAMCGFTVKE ISTTKDGDID LEKLRQMVGA
210 220 230 240 250
KTAGIMLTNP STLGVFERQI SEVAKIIHNA GGLLYYDGAN LNAILGKYRP
260 270 280 290 300
GDMGFDVMHL NLHKTFATPH GGGGPGAGPV AAGPRLSKFL PVPMVGKNKE
310 320 330 340 350
GYDWLTEKEC PKSIGRLSAF MGNSGVLLRA YIYLRLLGKE GLSRVAEFST
360 370 380 390 400
LNANYLMKRL EQLGFTLAFP NRRASHEFII TLKPLTRAYG VTALDIAKRL
410 420 430 440 450
LDYGFHAPTI YFPLLVPECL LIEPTETESK QTLDHFIEAM EKILTEIKTT
460 470 480 490
PDLLRNAPHQ QLINRLDEVK AARELDLRWY PIAKETEIFI Q
Length:491
Mass (Da):54,647
Last modified:December 16, 2008 - v1
Checksum:i7BCD7C9D7CCD45AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001020 Genomic DNA. Translation: ACJ19603.1.
RefSeqiWP_005770513.1. NC_011528.1.
YP_002304748.1. NC_011528.1.

Genome annotation databases

EnsemblBacteriaiACJ19603; ACJ19603; CbuK_0295.
GeneIDi7014809.
KEGGicbc:CbuK_0295.
PATRICi17916001. VBICoxBur77120_0329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001020 Genomic DNA. Translation: ACJ19603.1 .
RefSeqi WP_005770513.1. NC_011528.1.
YP_002304748.1. NC_011528.1.

3D structure databases

ProteinModelPortali B6J4T8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 434924.CbuK_0295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ19603 ; ACJ19603 ; CbuK_0295 .
GeneIDi 7014809.
KEGGi cbc:CbuK_0295.
PATRICi 17916001. VBICoxBur77120_0329.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CBUR434924:GHWU-294-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
    Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
    Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CbuK_Q154.

Entry informationi

Entry nameiGCSPB_COXB1
AccessioniPrimary (citable) accession number: B6J4T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: October 1, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3