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Protein

dCTP deaminase

Gene

dcd

Organism
Coxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:CbuG_0334
OrganismiCoxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212))
Taxonomic identifieri434923 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000964191 – 188dCTP deaminaseAdd BLAST188

Structurei

3D structure databases

ProteinModelPortaliB6J3W2.
SMRiB6J3W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228600.
KOiK01494.
OMAiCISYGLS.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiView protein in InterPro
IPR011962. dCTP_deaminase.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

B6J3W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKSDKWIR RMAESHQLIY PFEPKQVRET PSGKVISYGT SSYGYDVRCA
60 70 80 90 100
DEFKIFTNIN ASIVDPKNFD PNGFIDLKAN VCIIPPNSFV LARTVEYFKI
110 120 130 140 150
PRNILTICLG KSTYARCGII VNVTPLEPEW EGHVTLEFSN TTNLPAKIYA
160 170 180
NEGVAQMLFL ESDEVCDISY KDRGGKYQGQ KGVTLPVA
Length:188
Mass (Da):21,135
Last modified:December 16, 2008 - v1
Checksum:i3AE4A62920DE4C78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001019 Genomic DNA. Translation: ACJ17769.1.
RefSeqiWP_005770557.1. NC_011527.1.

Genome annotation databases

EnsemblBacteriaiACJ17769; ACJ17769; CbuG_0334.
KEGGicbg:CbuG_0334.
PATRICi17911644. VBICoxBur10955_0313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001019 Genomic DNA. Translation: ACJ17769.1.
RefSeqiWP_005770557.1. NC_011527.1.

3D structure databases

ProteinModelPortaliB6J3W2.
SMRiB6J3W2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ17769; ACJ17769; CbuG_0334.
KEGGicbg:CbuG_0334.
PATRICi17911644. VBICoxBur10955_0313.

Phylogenomic databases

HOGENOMiHOG000228600.
KOiK01494.
OMAiCISYGLS.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiView protein in InterPro
IPR011962. dCTP_deaminase.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCD_COXB2
AccessioniPrimary (citable) accession number: B6J3W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: February 15, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.