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Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

pckA

Organism
Coxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461SubstrateUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Metal bindingi186 – 1861ManganeseUniRule annotation
Binding sitei186 – 1861ATPUniRule annotation
Binding sitei186 – 1861SubstrateUniRule annotation
Metal bindingi205 – 2051Manganese; via tele nitrogenUniRule annotation
Binding sitei205 – 2051ATPUniRule annotation
Metal bindingi242 – 2421ManganeseUniRule annotation
Binding sitei270 – 2701ATPUniRule annotation
Binding sitei306 – 3061ATPUniRule annotation
Binding sitei306 – 3061SubstrateUniRule annotation
Binding sitei433 – 4331ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi221 – 2299ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR434923:GC8S-2088-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
Short name:
PCKUniRule annotation
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckAUniRule annotation
Ordered Locus Names:CbuG_2094
OrganismiCoxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212))
Taxonomic identifieri434923 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Phosphoenolpyruvate carboxykinase [ATP]PRO_1000125059Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000271471.
KOiK01610.
OMAiRFIVKEP.

Family and domain databases

CDDicd00484. PEPCK_ATP. 1 hit.
Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6J3V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQIAARVTY INLSPDELIQ HAVKNGEGVL SSTGALAVTT GKRTGRSPKD
60 70 80 90 100
RFIVKDEQTA DQVAWGNINQ PVEQRTFDQL WERALRYLSE RAVYISHLQV
110 120 130 140 150
GADDNYFLPL KVVTEFAWHN LFACDLFIRP SGDHANGKPS WVILSAPGLK
160 170 180 190 200
TDPERDGVNS DGAVMINLSQ RRVLLVGMPY AGEIKKAMFS VLNYLLPPHD
210 220 230 240 250
VLPMHCAANA GQSGDVALFF GLSGTGKTTL SADPHRFLIG DDEHGWSATS
260 270 280 290 300
VFNFEGGCYA KCIDLSQERE PMIWNAIRHG AIMENVVLDE NGVPDYADAR
310 320 330 340 350
LTQNSRAAYP REYIPLRVEN NRGRPPDAVL FLTCDLDGVL PPVALLTKEQ
360 370 380 390 400
AAYYFLSGYT ALVGSTEVGS VKGVTSTFST CFGAPFFPRP PTVYAELLMK
410 420 430 440 450
RIEATGCQVY LVNTGWTGGA YGKGGERFSI PTTRAIVNAV LSGKLKEGPT
460 470 480 490 500
EVLSGFNLTI PKSALGVDDH LLNPRKTWED VSAYDVRAQR LIQKFRENFE
510
KFKVPAAIRE AGPSDVH
Length:517
Mass (Da):56,801
Last modified:December 16, 2008 - v1
Checksum:i65F664C649A23EAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001019 Genomic DNA. Translation: ACJ19327.1.
RefSeqiWP_012570560.1. NC_011527.1.

Genome annotation databases

EnsemblBacteriaiACJ19327; ACJ19327; CbuG_2094.
KEGGicbg:CbuG_2094.
PATRICi17915329. VBICoxBur10955_2103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001019 Genomic DNA. Translation: ACJ19327.1.
RefSeqiWP_012570560.1. NC_011527.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ19327; ACJ19327; CbuG_2094.
KEGGicbg:CbuG_2094.
PATRICi17915329. VBICoxBur10955_2103.

Phylogenomic databases

HOGENOMiHOG000271471.
KOiK01610.
OMAiRFIVKEP.

Enzyme and pathway databases

UniPathwayiUPA00138.
BioCyciCBUR434923:GC8S-2088-MONOMER.

Family and domain databases

CDDicd00484. PEPCK_ATP. 1 hit.
Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP. 1 hit.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
IPR015994. PEPCK_ATP_CS.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
TIGRFAMsiTIGR00224. pckA. 1 hit.
PROSITEiPS00532. PEPCK_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCKA_COXB2
AccessioniPrimary (citable) accession number: B6J3V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.