Reviewed, UniProtKB/Swiss-Prot B6J3T7 (AROD_COXB2)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	CbuG_2076

Organism

Coxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212)) [Complete proteome] [HAMAP]

Taxonomic identifier

434923 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000099903
Sites
	Active site	118	1	Proton acceptor By similarity
	Active site	145	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B6J3T7-1 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: C80AF9E997D8B2EC	FASTA	233	26,508
	10 20 30 40 50 60 MLNTPRICVV VIGKTLEEFL SQLEAAQTAV DFVELRIDYL EQINPNWVRI IKNHTHKKAI 70 80 90 100 110 120 LCCRARADGG KFLGTPEAQQ EILQAGNDLG FDYLDIDLPV ANKISIHEKK AKIIISYHNF 130 140 150 160 170 180 LHTPPITELN FLLENMRLFN PDVFKFATKS EQYEDVKTLF KLLINKKNNE NMIVLGMGEQ 190 200 210 220 230 GKIIRLLSPL LGGYLTFSSI NGAISAPGQI DFKTMQDFYQ RFYKISSPLK GED

References

[1]

"Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella." Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A. Infect. Immun. 77:642-656(2009) [PubMed: 19047403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001019 Genomic DNA. Translation: ACJ19309.1.
RefSeq	YP_002304454.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7014492.
GenomeReviews	Gene locus CbuG_2076 in contig CP001019_GR.
KEGG	cbg:CbuG_2076.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00214. [Tree]
InterPro	IPR018508. 3-dehydroquinate_DH_AS. IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. aroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_COXB2

Accession

Primary (citable) accession number: B6J3T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	December 16, 2008
Last modified:	September 22, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)