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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Coxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:CbuG_2005
OrganismiCoxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212))
Taxonomic identifieri434923 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000983971 – 314Methionyl-tRNA formyltransferaseAdd BLAST314

Proteomic databases

PRIDEiB6J3C2

Structurei

3D structure databases

ProteinModelPortaliB6J3C2
SMRiB6J3C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 114Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

B6J3C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKIVFAGT PQFAVPTLRA LIDSSHRVLA VYTQPDRPSG RGQKIMESPV
60 70 80 90 100
KEIARQNEIP IIQPFSLRDE VEQEKLIAMN ADVMVVVAYG LILPKKALNA
110 120 130 140 150
FRLGCVNVHA SLLPRWRGAA PIQRAILAGD RETGISIMQM NEGLDTGDVL
160 170 180 190 200
AKSACVISSE DTAADLHDRL SLIGADLLLE SLAKLEKGDI KLEKQDEASA
210 220 230 240 250
TYASKIQKQE ALIDWRKSAV EIARQVRAFN PTPIAFTYFE GQPMRIWRAT
260 270 280 290 300
VVDEKTDFEP GVLVDADKKG ISIAAGSGIL RLHQLQLPGK RVCSAGDFIN
310
AHGDKLIPGK TVFG
Length:314
Mass (Da):34,288
Last modified:December 16, 2008 - v1
Checksum:i11A4B3CCB9ED0AD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001019 Genomic DNA Translation: ACJ19247.1
RefSeqiWP_010958586.1, NC_011527.1

Genome annotation databases

EnsemblBacteriaiACJ19247; ACJ19247; CbuG_2005
GeneIDi31484676
KEGGicbg:CbuG_2005

Similar proteinsi

Entry informationi

Entry nameiFMT_COXB2
AccessioniPrimary (citable) accession number: B6J3C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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