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B6J2H7 (GCSPA_COXB2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:CbuG_0096
OrganismCoxiella burnetii (strain CbuG_Q212) (Coxiella burnetii (strain Q212)) [Complete proteome] [HAMAP]
Taxonomic identifier434923 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132477

Sequences

Sequence LengthMass (Da)Tools
B6J2H7 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: E02EB4C879F0DBB8

FASTA44648,465
        10         20         30         40         50         60 
MPFIPHTPDD IEKMLAVIGA ESIDQLFDEI PSALANIQQV PPGLNEAGIT RLMEKREPNK 

        70         80         90        100        110        120 
QLCFIGAGAY EHHIPAAVWE IATRGEFYTA YTPYQAEASQ GSLQLIYEYQ TMMAELMAMD 

       130        140        150        160        170        180 
VSNASLYDGA SALAEAALMA VRIKRGKAQR ILVPASVNPF YRKVLSSIVE QQKINVEIIP 

       190        200        210        220        230        240 
FDPTMGIVNS ELLKAKNAEG AAAIIIPQPN FFGCLEAVDV LTDWAHANDL LVIASVNPTA 

       250        260        270        280        290        300 
MALLKPPGQW GQKGADIVCG EGQPLGVPLA SGGPYFGFMC CKKDYVRQLP GRIVGRTVDK 

       310        320        330        340        350        360 
KGREGFTLTL QAREQHIRRS KATSNICTNQ GLAVVAATIY LSLLGATGLR EVALASHTQS 

       370        380        390        400        410        420 
RDLFQRLSAV KGVSPVFSSP IFHEFVVRLE KPVEEVLAAM AEQGIQAGFS LKNDYPKLGN 

       430        440 
GLLICVTDTK TDDDLMAYEN ALRSIQ 

« Hide

References

[1]"Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella."
Beare P.A., Unsworth N., Andoh M., Voth D.E., Omsland A., Gilk S.D., Williams K.P., Sobral B.W., Kupko J.J. III, Porcella S.F., Samuel J.E., Heinzen R.A.
Infect. Immun. 77:642-656(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CbuG_Q212.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001019 Genomic DNA. Translation: ACJ17551.1.
RefSeqYP_002302696.1. NC_011527.1.

3D structure databases

ProteinModelPortalB6J2H7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING434923.CbuG_0096.

Proteomic databases

PRIDEB6J2H7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ17551; ACJ17551; CbuG_0096.
GeneID7012513.
KEGGcbg:CbuG_0096.
PATRIC17911186. VBICoxBur10955_0089.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycCBUR434923:GC8S-96-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_COXB2
AccessionPrimary (citable) accession number: B6J2H7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families