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B6IYP5

- MDH_RHOCS

UniProt

B6IYP5 - MDH_RHOCS

Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADUniRule annotation
    Binding sitei85 – 851SubstrateUniRule annotation
    Binding sitei91 – 911SubstrateUniRule annotation
    Binding sitei98 – 981NADUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Active sitei178 – 1781Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156NADUniRule annotation
    Nucleotide bindingi121 – 1233NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRCEN414684:GHCM-4054-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:RC1_4080
    OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
    Taxonomic identifieri414684 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
    ProteomesiUP000001591: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Malate dehydrogenasePRO_1000126148Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi414684.RC1_4080.

    Structurei

    3D structure databases

    ProteinModelPortaliB6IYP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6IYP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARKKIALVG AGQIGGTLAL LAGQKELGDI VLLDIPDAEG VAKGKALDIA    50
    EASPVEGFDA GYTGTSNYAD LAGADVVIVT AGVPRKPGMS RDDLVGINAR 100
    IIKAVGEGIR THAPDAFVIV ITNPLDAMVG LMQQVTGFDP AKVVGMAGVL 150
    DSARFRWFLA EEFKVSVEDV TAFVLGGHGD TMVPSVRYST VAGIPLPDLV 200
    KMGWTTQEKL DQIVQRTRDG GAEIVGLLKT GSAFYAPAAS AIAMAESYLK 250
    DKKRVMPCAA RLTGQYGVDG LYIGVPVVIG AGGVEKIVEI ELNAEEQAMF 300
    DKSVAAVKSL VEVTAKVAG 319
    Length:319
    Mass (Da):33,185
    Last modified:December 16, 2008 - v1
    Checksum:iDA50A524CBB0EC1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000613 Genomic DNA. Translation: ACJ01419.1.
    RefSeqiWP_012569192.1. NC_011420.2.
    YP_002300231.1. NC_011420.2.

    Genome annotation databases

    EnsemblBacteriaiACJ01419; ACJ01419; RC1_4080.
    GeneIDi7008844.
    KEGGirce:RC1_4080.
    PATRICi23323334. VBIRhoCen1465_3973.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000613 Genomic DNA. Translation: ACJ01419.1 .
    RefSeqi WP_012569192.1. NC_011420.2.
    YP_002300231.1. NC_011420.2.

    3D structure databases

    ProteinModelPortali B6IYP5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 414684.RC1_4080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ01419 ; ACJ01419 ; RC1_4080 .
    GeneIDi 7008844.
    KEGGi rce:RC1_4080.
    PATRICi 23323334. VBIRhoCen1465_3973.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci RCEN414684:GHCM-4054-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rhodospirillum centenum."
      Touchman J.W., Bauer C., Blankenship R.E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51521 / SW.

    Entry informationi

    Entry nameiMDH_RHOCS
    AccessioniPrimary (citable) accession number: B6IYP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3