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Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei98NADUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi121 – 123NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:RC1_4080
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001591 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001261481 – 319Malate dehydrogenaseAdd BLAST319

Interactioni

Protein-protein interaction databases

STRINGi414684.RC1_4080.

Structurei

3D structure databases

ProteinModelPortaliB6IYP5.
SMRiB6IYP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR11540:SF31. PTHR11540:SF31. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B6IYP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKIALVG AGQIGGTLAL LAGQKELGDI VLLDIPDAEG VAKGKALDIA
60 70 80 90 100
EASPVEGFDA GYTGTSNYAD LAGADVVIVT AGVPRKPGMS RDDLVGINAR
110 120 130 140 150
IIKAVGEGIR THAPDAFVIV ITNPLDAMVG LMQQVTGFDP AKVVGMAGVL
160 170 180 190 200
DSARFRWFLA EEFKVSVEDV TAFVLGGHGD TMVPSVRYST VAGIPLPDLV
210 220 230 240 250
KMGWTTQEKL DQIVQRTRDG GAEIVGLLKT GSAFYAPAAS AIAMAESYLK
260 270 280 290 300
DKKRVMPCAA RLTGQYGVDG LYIGVPVVIG AGGVEKIVEI ELNAEEQAMF
310
DKSVAAVKSL VEVTAKVAG
Length:319
Mass (Da):33,185
Last modified:December 16, 2008 - v1
Checksum:iDA50A524CBB0EC1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA. Translation: ACJ01419.1.
RefSeqiWP_012569192.1. NC_011420.2.

Genome annotation databases

EnsemblBacteriaiACJ01419; ACJ01419; RC1_4080.
KEGGirce:RC1_4080.

Similar proteinsi

Entry informationi

Entry nameiMDH_RHOCS
AccessioniPrimary (citable) accession number: B6IYP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families