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B6IXI3 (GCSPA_RHOCS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:RC1_3658
OrganismRhodospirillum centenum (strain ATCC 51521 / SW) [Complete proteome] [HAMAP]
Taxonomic identifier414684 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000132487

Sequences

Sequence LengthMass (Da)Tools
B6IXI3 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: 2FDBCB65D779E633

FASTA44947,725
        10         20         30         40         50         60 
MRYLPLTEAD RQAMLARIGV PDVDALFRDV PQAARLTAPI DGLPLHMGEL EVDRLLSGMA 

        70         80         90        100        110        120 
AKNLTAGSVP SFLGAGAYRH HVPASVDQML LRGEFLTSYT PYQPEVAQGT LQYLFEFQTQ 

       130        140        150        160        170        180 
VAEITGMEVA NASMYDGATG TAEAVLMATR LTRRSKAVLS GGLHPHYREV VATTCGVLGM 

       190        200        210        220        230        240 
EVAAQAPDPT DAEDLLPLVD DATACVVVQT PSLFGHPRDL SELAAACHAK GALLIAVVTE 

       250        260        270        280        290        300 
VVSLGLLTPP GRMGADIVVC EGQSIGNPLN FGGPHVGLFA TREKFVRQMP GRLCGQTADA 

       310        320        330        340        350        360 
EGKRGFVLTL STREQHIRRE KATSNICTNS GLCALAFTIH MALLGGEGFA RLARLNHAKA 

       370        380        390        400        410        420 
VTLADRLAAV PGVEVLNGAF FNEFTLRLPR PAAPVVEALA QRRILAGVPV SRLYPGEAGL 

       430        440 
ETLLLVAATE TNTEADMDAL VHGLQEVLR 

« Hide

References

[1]"Genome sequence of Rhodospirillum centenum."
Touchman J.W., Bauer C., Blankenship R.E.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51521 / SW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000613 Genomic DNA. Translation: ACJ01007.1.
RefSeqYP_002299819.1. NC_011420.2.

3D structure databases

ProteinModelPortalB6IXI3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING414684.RC1_3658.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ01007; ACJ01007; RC1_3658.
GeneID7008423.
KEGGrce:RC1_3658.
PATRIC23322488. VBIRhoCen1465_3557.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycRCEN414684:GHCM-3633-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_RHOCS
AccessionPrimary (citable) accession number: B6IXI3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families