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B6IWI6

- HIS4_RHOCS

UniProt

B6IWI6 - HIS4_RHOCS

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81Proton acceptorUniRule annotation
    Active sitei129 – 1291Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciRCEN414684:GHCM-3274-MONOMER.
    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:hisAUniRule annotation
    Ordered Locus Names:RC1_3298
    OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
    Taxonomic identifieri414684 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
    ProteomesiUP000001591: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2472471-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_1000190548Add
    BLAST

    Proteomic databases

    PRIDEiB6IWI6.

    Interactioni

    Protein-protein interaction databases

    STRINGi414684.RC1_3298.

    Structurei

    3D structure databases

    ProteinModelPortaliB6IWI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    OMAiGWAEETD.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B6IWI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIYPAIDLK DGQAVRLLRG DMDQATVFNP DPAAQAAAFQ DQGFRWLHLV    50
    DLNGAFAGRP VNADAVSRIL ERVTIPVQLG GGIRDMATIE EWLGRGIRRV 100
    ILGTVALRDP DLVKDACRAF PGRICVGIDA RDGHVAVEGW ATTSDVRALD 150
    LALRFEDAGV AAIVYTDINR DGAMGGVNVE ATADLAVHLT TPVIASGGVH 200
    ALSDLLALKA EAETGIEGVI VGRALYDGRI DPRQALALTA GPEDARC 247
    Length:247
    Mass (Da):26,155
    Last modified:December 16, 2008 - v1
    Checksum:i29BB0E4E27BC26F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000613 Genomic DNA. Translation: ACJ00660.1.
    RefSeqiWP_012568438.1. NC_011420.2.
    YP_002299472.1. NC_011420.2.

    Genome annotation databases

    EnsemblBacteriaiACJ00660; ACJ00660; RC1_3298.
    GeneIDi7008064.
    KEGGirce:RC1_3298.
    PATRICi23321772. VBIRhoCen1465_3205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000613 Genomic DNA. Translation: ACJ00660.1 .
    RefSeqi WP_012568438.1. NC_011420.2.
    YP_002299472.1. NC_011420.2.

    3D structure databases

    ProteinModelPortali B6IWI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 414684.RC1_3298.

    Proteomic databases

    PRIDEi B6IWI6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ00660 ; ACJ00660 ; RC1_3298 .
    GeneIDi 7008064.
    KEGGi rce:RC1_3298.
    PATRICi 23321772. VBIRhoCen1465_3205.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    OMAi GWAEETD.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    BioCyci RCEN414684:GHCM-3274-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Rhodospirillum centenum."
      Touchman J.W., Bauer C., Blankenship R.E.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51521 / SW.

    Entry informationi

    Entry nameiHIS4_RHOCS
    AccessioniPrimary (citable) accession number: B6IWI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3