B6IW69 (B6IW69_RHOCS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase HAMAP MF_00061
Short name=CMK HAMAP MF_00061
EC=2.7.1.148 HAMAP MF_00061

Alternative name(s):
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase HAMAP MF_00061

Gene names

Name:	ispE HAMAP MF_00061 EMBL ACJ00543.1
Ordered Locus Names:	RC1_3179

Organism

Rhodospirillum centenum (strain ATCC 51521 / SW) [Complete proteome] [HAMAP] EMBL ACJ00543.1

Taxonomic identifier

414684 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol By similarity. HAMAP MF_00061
Catalytic activity	ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00061
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6. HAMAP MF_00061
Sequence similarities	Belongs to the GHMP kinase family. IspE subfamily. HAMAP MF_00061

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00061
Ligand	ATP-binding HAMAP MF_00061 RuleBase RU003563 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00061 RuleBase RU003563 EMBL ACJ00543.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	101 – 111	11	ATP By similarity HAMAP MF_00061
Sites
	Active site	14	1	By similarity HAMAP MF_00061
	Active site	143	1	By similarity HAMAP MF_00061

Sequences

	Sequence		Length	Mass (Da)
	B6IW69 [UniParc]. Last modified December 16, 2008. Version 1. Checksum: 02DAD8B2795E03EF	FASTA	300	30,873
	10 20 30 40 50 60 MTVPLPVRAA APAKLNLYLH VLGRRPDGYH LLDSLVVFAG LCDVVEVAPA ETFRLCIDGP 70 80 90 100 110 120 FAAPLRAEDP ERNLVTRACR RLAEAVGRAP DVAVTLHKRL PVAGGIGGGS SDAAAALRAL 130 140 150 160 170 180 AALWGLDPDD PRPAAVAPGL GADVPVCLHG RSAYFGGIGD VIDPAPALPP VWLVLVNPGI 190 200 210 220 230 240 GLGTKEVFGA RRDGFSTAGR LERAPADLSD FVTMLEERGN DLMAPAIALA PVVAEVLDAL 250 260 270 280 290 300 RGTAGCRLAR MSGSGATCFG LFGSETDARA AAAGLRAARP GWWAEAAPLL PQVPAVEIAG

References

[1]	"Genome sequence of Rhodospirillum centenum." Touchman J.W., Bauer C., Blankenship R.E. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000613 Genomic DNA. Translation: ACJ00543.1.
RefSeq	YP_002299355.1. NC_011420.2.
3D structure databases
ProteinModelPortal	B6IW69.
ModBase	Search...
Protein-protein interaction databases
STRING	B6IW69.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7007945.
GenomeReviews	Gene locus RC1_3179 in contig CP000613_GR.
KEGG	rce:RC1_3179.
PATRIC	23321534. VBIRhoCen1465_3088.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734593.
OMA	CQLARMS.
ProtClustDB	CLSK2804690.
Family and domain databases
HAMAP	MF_00061. IspE. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR004424. IspE. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00919.
PANTHER	PTHR20861:SF2. IspE. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF010376. IspE. 1 hit.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00154. IspE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B6IW69_RHOCS

Accession

Primary (citable) accession number: B6IW69

Entry history

Integrated into UniProtKB/TrEMBL:	December 16, 2008
Last sequence update:	December 16, 2008
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)