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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi485 – 4851MagnesiumUniRule annotation
Metal bindingi491 – 4911MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciRCEN414684:GHCM-2895-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:RC1_2919
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001591 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Polyribonucleotide nucleotidyltransferasePRO_1000192486Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi414684.RC1_2919.

Structurei

3D structure databases

ProteinModelPortaliB6IVG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 61564KHUniRule annotationAdd
BLAST
Domaini621 – 68969S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6IVG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKVFRKEMM WGGRKLVLET GKVARQADGA VWASYGDTVV LATAVAAKAP
60 70 80 90 100
KPGVDFFPLT VNYQEKAFAA GKIPGGFFKR EGRPTEKEVL TSRLIDRPIR
110 120 130 140 150
PLFADGYRNE TQVIVTVLSH DLENDPDIVA MVATSAALTI SGIPFLGPIG
160 170 180 190 200
AARVGYKDGQ FVLNPTLEQV EASDLDLVVA GTTEGVLMVE SEAKELPEDV
210 220 230 240 250
MLGAVMFGHR EFQPVIDLII DLAEMAAKDP MAIPAPAYDK DAVKTRMAAL
260 270 280 290 300
IGQDVRQAYT LTVKQERYAA IGAAKLKALE TMVAEGTAPE AVASVFKELE
310 320 330 340 350
SDILRGSVIE TGKRIDGRTT VDIRPIVSQV GVLPRAHGSA LFTRGETQAL
360 370 380 390 400
VVATLGTNQD EQIVDALEGE YRESFMLHYN FPPYSVGEAG RMGSPGRREI
410 420 430 440 450
GHGKLAWRAV RPLLPTKETF PYTIRVVSEI TESNGSSSMA TVCGSSLSMM
460 470 480 490 500
DAGVPLPRPV AGIAMGLIKE GEKFAVLSDI LGDEDHLGDM DFKVAGTEKG
510 520 530 540 550
VTALQMDIKI TSITEEIMKI ALAQAKDGRV HILSEMNKAL NTAREAVNQN
560 570 580 590 600
APRITVINIP KDKIRDVIGS GGKVIREIVE QTGAKIDIED DGTVKVAAVD
610 620 630 640 650
GKASEAAIKW IKGIVAEPEV GEIYEGKVVK IMDFGAFVNF LGSRDGLVHI
660 670 680 690 700
SELKNERVAK VTDVVKQGDA VKVKVLGFDD RGKVKLSMKV VDQTTGEDLS

KKEEAEG
Length:707
Mass (Da):76,204
Last modified:December 15, 2008 - v1
Checksum:i2E0A2370687CF583
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA. Translation: ACJ00287.1.
RefSeqiWP_012568067.1. NC_011420.2.
YP_002299099.1. NC_011420.2.

Genome annotation databases

EnsemblBacteriaiACJ00287; ACJ00287; RC1_2919.
KEGGirce:RC1_2919.
PATRICi23321018. VBIRhoCen1465_2831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA. Translation: ACJ00287.1.
RefSeqiWP_012568067.1. NC_011420.2.
YP_002299099.1. NC_011420.2.

3D structure databases

ProteinModelPortaliB6IVG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi414684.RC1_2919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ00287; ACJ00287; RC1_2919.
KEGGirce:RC1_2919.
PATRICi23321018. VBIRhoCen1465_2831.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.
OrthoDBiEOG6WT8CC.

Enzyme and pathway databases

BioCyciRCEN414684:GHCM-2895-MONOMER.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Rhodospirillum centenum."
    Touchman J.W., Bauer C., Blankenship R.E.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51521 / SW.

Entry informationi

Entry nameiPNP_RHOCS
AccessioniPrimary (citable) accession number: B6IVG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2009
Last sequence update: December 15, 2008
Last modified: March 31, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.