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B6IV21

- B6IV21_RHOCS

UniProt

B6IV21 - B6IV21_RHOCS

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Protein

Kynureninase

Gene

kynU

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei99 – 991Pyridoxal phosphateUniRule annotation
Binding sitei168 – 1681Pyridoxal phosphateUniRule annotation
Binding sitei197 – 1971Pyridoxal phosphateUniRule annotation
Binding sitei200 – 2001Pyridoxal phosphateUniRule annotation
Binding sitei222 – 2221Pyridoxal phosphateUniRule annotation
Binding sitei252 – 2521Pyridoxal phosphateUniRule annotation
Binding sitei278 – 2781Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciRCEN414684:GHCM-2750-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:RC1_2772Imported
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)Imported
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001591: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei223 – 2231N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi414684.RC1_2772.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1294Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiVWDLAHS.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

B6IV21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLGRADLEA LDAADPLAPF RDEFALPEGV LYLDGNSLGA LPRATPARLA
60 70 80 90 100
RLVQEEWGRD LIRSWNTAGW IDLPRRVGEA IAPVVGAGPG QVIAADSTSV
110 120 130 140 150
NLFKLAAAAV GMRPGRRVIL SEPGNFPTDL YVLQGLAELL GDRVELVLAE
160 170 180 190 200
RHELADALDG DVALLLLTHV HYKTGRVHDL PGLTAAAHAA GALTLWDLSH
210 220 230 240 250
SAGALEVGLD AAGADFAVGC GYKYLNGGPG APAWLYVAQR HQDQVRPPLA
260 270 280 290 300
GWMGHAAPFA FEDRFRPADG MARQLCGTPG ILGMAALEEG VRIVARADRA
310 320 330 340 350
RLREKSRRMG DLFLALVAEQ CGPDTFALAC PADGAERGSQ VSLSHPEGYA
360 370 380 390 400
IIQALIARGV IGDFRAPDIL RFGFAPLYLR YTDIWDAVVH LAAVMRDGEW
410
QADRFRQRAA VT
Length:412
Mass (Da):44,151
Last modified:December 16, 2008 - v1
Checksum:iBB5B5D213F424173
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000613 Genomic DNA. Translation: ACJ00145.1.
RefSeqiWP_012567925.1. NC_011420.2.
YP_002298957.1. NC_011420.2.

Genome annotation databases

EnsemblBacteriaiACJ00145; ACJ00145; RC1_2772.
GeneIDi7007540.
KEGGirce:RC1_2772.
PATRICi23320732. VBIRhoCen1465_2689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000613 Genomic DNA. Translation: ACJ00145.1 .
RefSeqi WP_012567925.1. NC_011420.2.
YP_002298957.1. NC_011420.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 414684.RC1_2772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ00145 ; ACJ00145 ; RC1_2772 .
GeneIDi 7007540.
KEGGi rce:RC1_2772.
PATRICi 23320732. VBIRhoCen1465_2689.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242437.
KOi K01556.
OMAi VWDLAHS.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci RCEN414684:GHCM-2750-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rhodospirillum centenum."
    Touchman J.W., Bauer C., Blankenship R.E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51521 / SWImported.

Entry informationi

Entry nameiB6IV21_RHOCS
AccessioniPrimary (citable) accession number: B6IV21
Entry historyi
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3