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B6IU54 (SYL_RHOCS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:RC1_2551
OrganismRhodospirillum centenum (strain ATCC 51521 / SW) [Complete proteome] [HAMAP]
Taxonomic identifier414684 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum

Protein attributes

Sequence length865 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 865865Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000091352

Regions

Motif41 – 5111"HIGH" region HAMAP-Rule MF_00049
Motif614 – 6185"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6171ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B6IU54 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: E06C81181326B1AF

FASTA86595,609
        10         20         30         40         50         60 
MSRYNVRETE AKWQAAWADA GSFAVTADPA KPKYYVLEMF PYPSGRIHMG HVRNYTMGDV 

        70         80         90        100        110        120 
VARFKRAKGF NVLHPMGWDA FGLPAENAAL EKGVHPGKWT YENIATMRGQ LQTMGLAIDW 

       130        140        150        160        170        180 
SREVATCRPE YYRHEQKIFL DFLKAGLAYR KESWVNWDPV DNTVLANEQV VDGRGWRTGA 

       190        200        210        220        230        240 
LVEKRKLSQW FLKITHFADD LLEALKGLER WPDKVRTMQE NWIGRSTGCR FFFRMSDGHP 

       250        260        270        280        290        300 
DLEVFTTRPD TLYGASFVAI SPNHPLAATL AAGNPALADF IAECNRTSTS EADIETAEKK 

       310        320        330        340        350        360 
GFATGVTAEH PFVPGWTLPV YVANFVLMEY GTGAIFGCPA HDQRDLDFAR KYGLPVKPVV 

       370        380        390        400        410        420 
IPEGQDPAAF AVADEAYTGP GVLRNSDFLD GLGVEEAKAA AIRRIEEAGR GQGTTMYRLR 

       430        440        450        460        470        480 
DWGVSRQRYW GCPIPVIHCP KCGAVPVPEA QLPVTLPDDV TFDAPGNPLA RHPTWKHVAC 

       490        500        510        520        530        540 
PCCGGAAERE TDTFDTFIES SWYFLRFADP RNGTLAFDPE LVKYWLPVDQ YIGGVEHAVL 

       550        560        570        580        590        600 
HLLYARFWTR ALAHCGYLDL AEPFAGLFTQ GMVTHATYQG TDGKWLFPAE VEFREGAMVK 

       610        620        630        640        650        660 
SDDGTAVTVG PIIKMSKSKK NVVDPQQIIE SYGADAARLF MMSDSPPDRD LEWTTAGIDG 

       670        680        690        700        710        720 
AWRYINRLWR LVTEPGFDLP APGTPAPASF GEEATAIRRL AHKAAQQIGE DIEGFRFNSS 

       730        740        750        760        770        780 
VARLRSFSNG VQDAFAKLAA KAAAGTAPAA DEAWAAREAL EMLARMVEPM MPHLAHEMWV 

       790        800        810        820        830        840 
ELGHAGLLLD RPWPAVDAAL VVEDTVTVAV QVNGKLRATI NLRRDAGNEE AQAAALADPA 

       850        860 
VQKAVEGKPL RKVVVVPNRI VNVVV 

« Hide

References

[1]"Genome sequence of Rhodospirillum centenum."
Touchman J.W., Bauer C., Blankenship R.E.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51521 / SW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000613 Genomic DNA. Translation: ACI99931.1.
RefSeqYP_002298744.1. NC_011420.2.

3D structure databases

ProteinModelPortalB6IU54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING414684.RC1_2551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACI99931; ACI99931; RC1_2551.
GeneID7007319.
KEGGrce:RC1_2551.
PATRIC23320296. VBIRhoCen1465_2479.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAPVIHCPK.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycRCEN414684:GHCM-2529-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_RHOCS
AccessionPrimary (citable) accession number: B6IU54
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries