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B6IU54

- SYL_RHOCS

UniProt

B6IU54 - SYL_RHOCS

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Protein
Leucine--tRNA ligase
Gene
leuS, RC1_2551
Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei617 – 6171ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCEN414684:GHCM-2529-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RC1_2551
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001591: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Leucine--tRNA ligaseUniRule annotation
PRO_1000091352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi414684.RC1_2551.

Structurei

3D structure databases

ProteinModelPortaliB6IU54.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionUniRule annotation
Add
BLAST
Motifi614 – 6185"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6IU54-1 [UniParc]FASTAAdd to Basket

« Hide

MSRYNVRETE AKWQAAWADA GSFAVTADPA KPKYYVLEMF PYPSGRIHMG    50
HVRNYTMGDV VARFKRAKGF NVLHPMGWDA FGLPAENAAL EKGVHPGKWT 100
YENIATMRGQ LQTMGLAIDW SREVATCRPE YYRHEQKIFL DFLKAGLAYR 150
KESWVNWDPV DNTVLANEQV VDGRGWRTGA LVEKRKLSQW FLKITHFADD 200
LLEALKGLER WPDKVRTMQE NWIGRSTGCR FFFRMSDGHP DLEVFTTRPD 250
TLYGASFVAI SPNHPLAATL AAGNPALADF IAECNRTSTS EADIETAEKK 300
GFATGVTAEH PFVPGWTLPV YVANFVLMEY GTGAIFGCPA HDQRDLDFAR 350
KYGLPVKPVV IPEGQDPAAF AVADEAYTGP GVLRNSDFLD GLGVEEAKAA 400
AIRRIEEAGR GQGTTMYRLR DWGVSRQRYW GCPIPVIHCP KCGAVPVPEA 450
QLPVTLPDDV TFDAPGNPLA RHPTWKHVAC PCCGGAAERE TDTFDTFIES 500
SWYFLRFADP RNGTLAFDPE LVKYWLPVDQ YIGGVEHAVL HLLYARFWTR 550
ALAHCGYLDL AEPFAGLFTQ GMVTHATYQG TDGKWLFPAE VEFREGAMVK 600
SDDGTAVTVG PIIKMSKSKK NVVDPQQIIE SYGADAARLF MMSDSPPDRD 650
LEWTTAGIDG AWRYINRLWR LVTEPGFDLP APGTPAPASF GEEATAIRRL 700
AHKAAQQIGE DIEGFRFNSS VARLRSFSNG VQDAFAKLAA KAAAGTAPAA 750
DEAWAAREAL EMLARMVEPM MPHLAHEMWV ELGHAGLLLD RPWPAVDAAL 800
VVEDTVTVAV QVNGKLRATI NLRRDAGNEE AQAAALADPA VQKAVEGKPL 850
RKVVVVPNRI VNVVV 865
Length:865
Mass (Da):95,609
Last modified:December 16, 2008 - v1
Checksum:iE06C81181326B1AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000613 Genomic DNA. Translation: ACI99931.1.
RefSeqiWP_012567713.1. NC_011420.2.
YP_002298744.1. NC_011420.2.

Genome annotation databases

EnsemblBacteriaiACI99931; ACI99931; RC1_2551.
GeneIDi7007319.
KEGGirce:RC1_2551.
PATRICi23320296. VBIRhoCen1465_2479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000613 Genomic DNA. Translation: ACI99931.1 .
RefSeqi WP_012567713.1. NC_011420.2.
YP_002298744.1. NC_011420.2.

3D structure databases

ProteinModelPortali B6IU54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 414684.RC1_2551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI99931 ; ACI99931 ; RC1_2551 .
GeneIDi 7007319.
KEGGi rce:RC1_2551.
PATRICi 23320296. VBIRhoCen1465_2479.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RCEN414684:GHCM-2529-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rhodospirillum centenum."
    Touchman J.W., Bauer C., Blankenship R.E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51521 / SW.

Entry informationi

Entry nameiSYL_RHOCS
AccessioniPrimary (citable) accession number: B6IU54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi