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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei617ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCEN414684:G1G8I-2454-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RC1_2551
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001591 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913521 – 865Leucine--tRNA ligaseAdd BLAST865

Proteomic databases

PRIDEiB6IU54

Interactioni

Protein-protein interaction databases

STRINGi414684.RC1_2551

Structurei

3D structure databases

ProteinModelPortaliB6IU54
SMRiB6IU54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi614 – 618"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B6IU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYNVRETE AKWQAAWADA GSFAVTADPA KPKYYVLEMF PYPSGRIHMG
60 70 80 90 100
HVRNYTMGDV VARFKRAKGF NVLHPMGWDA FGLPAENAAL EKGVHPGKWT
110 120 130 140 150
YENIATMRGQ LQTMGLAIDW SREVATCRPE YYRHEQKIFL DFLKAGLAYR
160 170 180 190 200
KESWVNWDPV DNTVLANEQV VDGRGWRTGA LVEKRKLSQW FLKITHFADD
210 220 230 240 250
LLEALKGLER WPDKVRTMQE NWIGRSTGCR FFFRMSDGHP DLEVFTTRPD
260 270 280 290 300
TLYGASFVAI SPNHPLAATL AAGNPALADF IAECNRTSTS EADIETAEKK
310 320 330 340 350
GFATGVTAEH PFVPGWTLPV YVANFVLMEY GTGAIFGCPA HDQRDLDFAR
360 370 380 390 400
KYGLPVKPVV IPEGQDPAAF AVADEAYTGP GVLRNSDFLD GLGVEEAKAA
410 420 430 440 450
AIRRIEEAGR GQGTTMYRLR DWGVSRQRYW GCPIPVIHCP KCGAVPVPEA
460 470 480 490 500
QLPVTLPDDV TFDAPGNPLA RHPTWKHVAC PCCGGAAERE TDTFDTFIES
510 520 530 540 550
SWYFLRFADP RNGTLAFDPE LVKYWLPVDQ YIGGVEHAVL HLLYARFWTR
560 570 580 590 600
ALAHCGYLDL AEPFAGLFTQ GMVTHATYQG TDGKWLFPAE VEFREGAMVK
610 620 630 640 650
SDDGTAVTVG PIIKMSKSKK NVVDPQQIIE SYGADAARLF MMSDSPPDRD
660 670 680 690 700
LEWTTAGIDG AWRYINRLWR LVTEPGFDLP APGTPAPASF GEEATAIRRL
710 720 730 740 750
AHKAAQQIGE DIEGFRFNSS VARLRSFSNG VQDAFAKLAA KAAAGTAPAA
760 770 780 790 800
DEAWAAREAL EMLARMVEPM MPHLAHEMWV ELGHAGLLLD RPWPAVDAAL
810 820 830 840 850
VVEDTVTVAV QVNGKLRATI NLRRDAGNEE AQAAALADPA VQKAVEGKPL
860
RKVVVVPNRI VNVVV
Length:865
Mass (Da):95,609
Last modified:December 16, 2008 - v1
Checksum:iE06C81181326B1AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA Translation: ACI99931.1
RefSeqiWP_012567713.1, NC_011420.2

Genome annotation databases

EnsemblBacteriaiACI99931; ACI99931; RC1_2551
KEGGirce:RC1_2551

Similar proteinsi

Entry informationi

Entry nameiSYL_RHOCS
AccessioniPrimary (citable) accession number: B6IU54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health