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B6IST7

- LPXB_RHOCS

UniProt

B6IST7 - LPXB_RHOCS

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRCEN414684:GHCM-1176-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:RC1_1194
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001591: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Lipid-A-disaccharide synthasePRO_1000205847Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi414684.RC1_1194.

Structurei

3D structure databases

ProteinModelPortaliB6IST7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiRRSEIRH.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B6IST7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPLLIFLIA GEPSGDVLGG RLMAALREAM EGHVEFAGVG GPRMAEQGLQ
60 70 80 90 100
SLFPMEDLAL FGLAELLPRL PTLLKRLDQT TKAVLERTPD AVVSIDAPDF
110 120 130 140 150
CFRVEQRLRR AGARMPLIHY VAPTVWAWRP GRARKVAKFL DHLLALLPFE
160 170 180 190 200
PPYFEAVGLP CTFVGHPVVE SGADAGDGER FRRRHGIAPD ATVLTVLPGS
210 220 230 240 250
RRSEVTKLLP DFGATLEILA SRYPDLQVVV PTVPGVAETV AEAVQSWPVP
260 270 280 290 300
AITLLGDADK YDAFAASTAA LAASGTVALE LALARVPAVI AYRIHPVSHA
310 320 330 340 350
LYRRFIRVRY VNLVNIMLDR PLVPELLQQD CTPDRLALAV DRLLNEPSAR
360 370 380 390 400
QEQIDGVTEV ARWLGQGDVP PSRRAAEAVL NVITKRVIAD RQGQTPGRSR

S
Length:401
Mass (Da):43,713
Last modified:December 16, 2008 - v1
Checksum:iC25BE37E998BB01F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000613 Genomic DNA. Translation: ACI98608.1.
RefSeqiWP_012566396.1. NC_011420.2.
YP_002297421.1. NC_011420.2.

Genome annotation databases

EnsemblBacteriaiACI98608; ACI98608; RC1_1194.
GeneIDi7005964.
KEGGirce:RC1_1194.
PATRICi23317596. VBIRhoCen1465_1149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000613 Genomic DNA. Translation: ACI98608.1 .
RefSeqi WP_012566396.1. NC_011420.2.
YP_002297421.1. NC_011420.2.

3D structure databases

ProteinModelPortali B6IST7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 414684.RC1_1194.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI98608 ; ACI98608 ; RC1_1194 .
GeneIDi 7005964.
KEGGi rce:RC1_1194.
PATRICi 23317596. VBIRhoCen1465_1149.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi RRSEIRH.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci RCEN414684:GHCM-1176-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rhodospirillum centenum."
    Touchman J.W., Bauer C., Blankenship R.E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51521 / SW.

Entry informationi

Entry nameiLPXB_RHOCS
AccessioniPrimary (citable) accession number: B6IST7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3