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B6IQI0 (GLPK_RHOCS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:RC1_0267
OrganismRhodospirillum centenum (strain ATCC 51521 / SW) [Complete proteome] [HAMAP]
Taxonomic identifier414684 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Rhodospirillum

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycerol kinase HAMAP MF_00186
PRO_1000098751

Regions

Nucleotide binding410 – 4145ATP By similarity

Sites

Binding site141Substrate By similarity
Binding site181ATP By similarity
Binding site841Substrate By similarity
Binding site1361Substrate By similarity
Binding site2451Substrate By similarity
Binding site2671ATP By similarity
Binding site3101ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
B6IQI0 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: 0294690138C2AF20

FASTA49853,540
        10         20         30         40         50         60 
MGERPCILAI DQGTTSSRAI VFDAAASVLA VAQTEFPQHY PADGWVEHDP EDIWRSTLEV 

        70         80         90        100        110        120 
SRQALQAAEA KGARVVAIGV TNQRETTLIW DRRTGRPIHN AIVWQDRRTA ADCAALAADG 

       130        140        150        160        170        180 
NETMVQARSG LLLDPYFSAT KAAWLLDHVS GARMRAENGH LAFGTVDSFL LWRLTGGRVH 

       190        200        210        220        230        240 
ATDATNASRT NLFNIHTQDW DPELLRLFRV PAALLPEVKD SADSFGQTDP ALFGRPLPVL 

       250        260        270        280        290        300 
GLVGDQQGAT IGQCCFEPGT IKSTYGTGCF VVVNTGATPV PSRHRLLTTI AYRIDGRTDY 

       310        320        330        340        350        360 
ALEGSIFIAG AAVQWLRDGL GIVRTAAETE ALAAGLPDNG GVYMVPAFTG LGAPHWDAAA 

       370        380        390        400        410        420 
RGTLTGLTRA SGRAHLARAA LEASCYQTCD LLAAMREDGA TPAALRVDGG MVANGWMVQF 

       430        440        450        460        470        480 
LADLLDLPVD RPVVMETTAL GAAYLAGRKA GLYGDFAEFT RVWRRDRRFD PAMPTSTRTA 

       490 
LLAGWQDAVR RTRSGAPD

« Hide

References

[1]"Genome sequence of Rhodospirillum centenum."
Touchman J.W., Bauer C., Blankenship R.E.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51521 / SW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000613 Genomic DNA. Translation: ACI97716.1.
RefSeqYP_002296529.1. NC_011420.2.

3D structure databases

ProteinModelPortalB6IQI0.
ModBaseSearch...

Protein-protein interaction databases

STRINGB6IQI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7005044.
GenomeReviewsGene locus RC1_0267 in contig CP000613_GR.
KEGGrce:RC1_0267.
PATRIC23315758. VBIRhoCen1465_0246.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMAKMAGSAQ.
ProtClustDBCLSK2398148.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. False negative.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_RHOCS
AccessionPrimary (citable) accession number: B6IQI0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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