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B6IP82

- DAPF_RHOCS

UniProt

B6IP82 - DAPF_RHOCS

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Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131SubstrateUniRule annotation
Binding sitei46 – 461SubstrateUniRule annotation
Binding sitei66 – 661SubstrateUniRule annotation
Active sitei75 – 751Proton donor/acceptorUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Sitei158 – 1581Important for catalytic activityUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Sitei207 – 2071Important for catalytic activityUniRule annotation
Active sitei216 – 2161Proton donor/acceptorUniRule annotation

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciRCEN414684:GHCM-2175-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
Short name:
DAP epimeraseUniRule annotation
Gene namesi
Name:dapFUniRule annotation
Ordered Locus Names:RC1_2197
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
ProteomesiUP000001591: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Diaminopimelate epimerasePRO_1000124429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 216

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi414684.RC1_2197.

Structurei

3D structure databases

ProteinModelPortaliB6IP82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate bindingUniRule annotation
Regioni75 – 773Substrate bindingUniRule annotation
Regioni207 – 2082Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the diaminopimelate epimerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiKMRIFNN.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6IP82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRRFLKMHG LGNDFVVLDA RRDPLPLTTA AARAIADRHT GVGCDQIVLL
60 70 80 90 100
EPPRHPAADL FMRILNPDGS ESGACGNATR CVASLVADGS GRAEVTVETA
110 120 130 140 150
TGLLRCRLRA DGSVTVDMGP ARLDWTQIPL AAAHDTLRVP AGAGPLQDAC
160 170 180 190 200
CVGMGNPHAV FFVDDAEAVD LATLGPVLEH HSLFPQRCNI EVAQVLAPDH
210 220 230 240 250
IRMRVWERGA GITRACGSGS CATLVAAARR GLTGRAAWIE LDGGRLWIEW
260 270 280 290
HGDGHVLMTG PVATAFTGEL SETLLPGSLP SETPLPETVP A
Length:291
Mass (Da):30,704
Last modified:December 16, 2008 - v1
Checksum:i0B546D7062B5895C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA. Translation: ACI99584.1.
RefSeqiYP_002298397.1. NC_011420.2.

Genome annotation databases

EnsemblBacteriaiACI99584; ACI99584; RC1_2197.
GeneIDi7006965.
KEGGirce:RC1_2197.
PATRICi23319582. VBIRhoCen1465_2127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA. Translation: ACI99584.1 .
RefSeqi YP_002298397.1. NC_011420.2.

3D structure databases

ProteinModelPortali B6IP82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 414684.RC1_2197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACI99584 ; ACI99584 ; RC1_2197 .
GeneIDi 7006965.
KEGGi rce:RC1_2197.
PATRICi 23319582. VBIRhoCen1465_2127.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi KMRIFNN.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci RCEN414684:GHCM-2175-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Rhodospirillum centenum."
    Touchman J.W., Bauer C., Blankenship R.E.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51521 / SW.

Entry informationi

Entry nameiDAPF_RHOCS
AccessioniPrimary (citable) accession number: B6IP82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3