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Protein

dCTP deaminase

Gene

dcd

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Proton donor/acceptorUniRule annotation1
Binding sitei152dCTPUniRule annotation1
Binding sitei166dCTPUniRule annotation1
Binding sitei176dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 112dCTP bindingUniRule annotation6
Nucleotide bindingi131 – 133dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciRCEN414684:G1G8I-1586-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:RC1_1654
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001591 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000964451 – 184dCTP deaminaseAdd BLAST184

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi414684.RC1_1654

Structurei

3D structure databases

ProteinModelPortaliB6INF8
SMRiB6INF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228600
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

B6INF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIMPDTWIR EMATTKGMIE PFTEAQKREG VISYGLSSYG YDARVADEFK
60 70 80 90 100
IFTNVDNAIV DPKQFDATSF VDRKTDVCII PANSFALART VEYFRIPRDV
110 120 130 140 150
LVICLGKSTY ARCGLIVNVT PLEPEWEGHV TLEISNTTPL PAKVYANEGL
160 170 180
CQFLFLKGEG TCEVSYADRA GKYMRQRGVT LPRL
Length:184
Mass (Da):20,661
Last modified:December 16, 2008 - v1
Checksum:iEC8B6F2F90AA3670
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA Translation: ACI99055.1
RefSeqiWP_012566840.1, NC_011420.2

Genome annotation databases

EnsemblBacteriaiACI99055; ACI99055; RC1_1654
KEGGirce:RC1_1654

Similar proteinsi

Entry informationi

Entry nameiDCD_RHOCS
AccessioniPrimary (citable) accession number: B6INF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: April 25, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health