ID   B6ID08_RAT              Unreviewed;        61 AA.
AC   B6ID08;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Metallothionein {ECO:0000256|RuleBase:RU000621};
GN   Name=Mt2A {ECO:0000313|EMBL:AAI68768.1, ECO:0000313|RGD:1592345};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAI68768.1};
RN   [1] {ECO:0000313|EMBL:AAI68768.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary gland {ECO:0000313|EMBL:AAI68768.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC       that bind various heavy metals; these proteins are transcriptionally
CC       regulated by both heavy metals and glucocorticoids.
CC       {ECO:0000256|ARBA:ARBA00002597}.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family.
CC       {ECO:0000256|ARBA:ARBA00007283, ECO:0000256|RuleBase:RU000621}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC168768; AAI68768.1; -; mRNA.
DR   RefSeq; NP_001131036.1; NM_001137564.1.
DR   AlphaFoldDB; B6ID08; -.
DR   SMR; B6ID08; -.
DR   GeneID; 689415; -.
DR   KEGG; rno:689415; -.
DR   CTD; 4502; -.
DR   RGD; 1592345; Mt2A.
DR   HOGENOM; CLU_171204_2_0_1; -.
DR   OMA; CCACCPV; -.
DR   PhylomeDB; B6ID08; -.
DR   ExpressionAtlas; B6ID08; baseline and differential.
DR   GO; GO:0046870; F:cadmium ion binding; IDA:RGD.
DR   GO; GO:0008270; F:zinc ion binding; IDA:RGD.
DR   GO; GO:0048143; P:astrocyte activation; IEP:RGD.
DR   GO; GO:0036018; P:cellular response to erythropoietin; ISO:RGD.
DR   GO; GO:0036016; P:cellular response to interleukin-3; ISO:RGD.
DR   GO; GO:0071294; P:cellular response to zinc ion; ISO:RGD.
DR   GO; GO:0010273; P:detoxification of copper ion; ISO:RGD.
DR   GO; GO:0006882; P:intracellular zinc ion homeostasis; ISO:RGD.
DR   GO; GO:0007263; P:nitric oxide mediated signal transduction; ISO:RGD.
DR   GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR   Gene3D; 4.10.10.10; Metallothionein Isoform II; 1.
DR   InterPro; IPR017854; Metalthion_dom_sf.
DR   InterPro; IPR023587; Metalthion_dom_sf_vert.
DR   InterPro; IPR000006; Metalthion_vert.
DR   InterPro; IPR018064; Metalthion_vert_metal_BS.
DR   PANTHER; PTHR23299; METALLOTHIONEIN; 1.
DR   PANTHER; PTHR23299:SF63; METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED; 1.
DR   Pfam; PF00131; Metallothio; 1.
DR   PRINTS; PR00860; MTVERTEBRATE.
DR   SUPFAM; SSF57868; Metallothionein; 1.
DR   PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
DR   Genevisible; B6ID08; RN.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000621};
KW   Metal-thiolate cluster {ECO:0000256|ARBA:ARBA00022851,
KW   ECO:0000256|RuleBase:RU000621}.
SQ   SEQUENCE   61 AA;  6145 MW;  D50D1306A5ED08E9 CRC64;
     MDPNCSCATD GSCSCAGSCK CKQCKCTSCK KSCCSCCPVG CAKCSQGCIC KEASDKCSCC
     A
//