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Protein

Metallothionein

Gene

Mt2A

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.UniRule annotation

GO - Molecular functioni

  • cadmium ion binding Source: RGD
  • zinc ion binding Source: RGD

GO - Biological processi

  • astrocyte activation Source: RGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate clusterUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
MetallothioneinUniRule annotation
Gene namesi
Name:Mt2AImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1592345. Mt2A.

Expressioni

Gene expression databases

BgeeiENSRNOG00000043098.
ExpressionAtlasiB6ID08. differential.
GenevisibleiB6ID08. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062585.

Structurei

3D structure databases

ProteinModelPortaliB6ID08.
SMRiB6ID08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallothionein superfamily. Type 1 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
HOVERGENiHBG096105.
KOiK14739.
OMAiNCSCATR.
PhylomeDBiB6ID08.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B6ID08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCATD GSCSCAGSCK CKQCKCTSCK KSCCSCCPVG CAKCSQGCIC
60
KEASDKCSCC A
Length:61
Mass (Da):6,145
Last modified:December 16, 2008 - v1
Checksum:iD50D1306A5ED08E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168768 mRNA. Translation: AAI68768.1.
RefSeqiNP_001131036.1. NM_001137564.1.
UniGeneiRn.115549.

Genome annotation databases

GeneIDi689415.
KEGGirno:689415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168768 mRNA. Translation: AAI68768.1.
RefSeqiNP_001131036.1. NM_001137564.1.
UniGeneiRn.115549.

3D structure databases

ProteinModelPortaliB6ID08.
SMRiB6ID08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi689415.
KEGGirno:689415.

Organism-specific databases

CTDi4502.
RGDi1592345. Mt2A.

Phylogenomic databases

eggNOGiENOG410JFS1. Eukaryota.
ENOG41113QR. LUCA.
HOVERGENiHBG096105.
KOiK14739.
OMAiNCSCATR.
PhylomeDBiB6ID08.

Gene expression databases

BgeeiENSRNOG00000043098.
ExpressionAtlasiB6ID08. differential.
GenevisibleiB6ID08. RN.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB6ID08_RAT
AccessioniPrimary (citable) accession number: B6ID08
Entry historyi
Integrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.