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B6IBD3 (AROD_ECOSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:ECSE_1816
OrganismEscherichia coli (strain SE11) [Complete proteome] [HAMAP]
Taxonomic identifier409438 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP-Rule MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP-Rule MF_00214

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2522523-dehydroquinate dehydratase HAMAP-Rule MF_00214
PRO_1000099906

Regions

Region46 – 483Substrate binding By similarity

Sites

Active site1431Proton donor/acceptor By similarity
Active site1701Schiff-base intermediate with substrate By similarity
Binding site821Substrate By similarity
Binding site2131Substrate By similarity
Binding site2321Substrate By similarity
Binding site2361Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B6IBD3 [UniParc].

Last modified December 16, 2008. Version 1.
Checksum: 01A85AA574A56C3B

FASTA25227,550
        10         20         30         40         50         60 
MKTVTVKDLV IGTGAPKIIV SLMAKDIARV KSEALAYREA DFDILEWRVD HFADLSNVES 

        70         80         90        100        110        120 
VMAAAKILRE TMPEKPLLFT FRSAKEGGEQ AISTEAYIAL NRAAIDSGLV DMIDLELFTG 

       130        140        150        160        170        180 
DDQVKETVAY AHAHDVKVVM SNHDFHKTPE AEEIIARLRK MQSFDADIPK IALMPQSTSD 

       190        200        210        220        230        240 
VLTLLTATLE MQEQYADRPI ITMSMAKTGV ISRLAGEVFG SAATFGAVKK ASAPGQISVN 

       250 
DLRTVLTILH QA

« Hide

References

[1]"Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult."
Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T., Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.
DNA Res. 15:375-386(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SE11.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009240 Genomic DNA. Translation: BAG77340.1.
RefSeqYP_002293091.1. NC_011415.1.

3D structure databases

ProteinModelPortalB6IBD3.
SMRB6IBD3. Positions 1-252.
ModBaseSearch...

Protein-protein interaction databases

STRING409438.ECSE_1816.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAG77340; BAG77340; ECSE_1816.
GeneID7000194.
KEGGecy:ECSE_1816.
PATRIC18422134. VBIEscCol83070_1962.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0710.
HOGENOMHOG000105514.
KOK03785.
OMAIIEWRVD.
ProtClustDBPRK02412.

Enzyme and pathway databases

BioCycECOL409438:GHUU-2007-MONOMER.
UniPathwayUPA00053; UER00086.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00214. AroD.
InterProIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. aroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_ECOSE
AccessionPrimary (citable) accession number: B6IBD3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 16, 2008
Last modified: May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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